Metabolic Health
Metabolic Health - Related Videos
06:59
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Cited by 7 •
2016
The goal of this protocol is to present a standard method to perform intravenous glucose tolerance tests (IVGTTs) to assess glycemic control in nonhuman primates and assess their metabolic status from healthy to dysmetabolic.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
10:19
An Introduction to Cell Metabolism
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2023
In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction to cell metabolism briefly...
08:28
Metabolic Labeling
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2023
Metabolic labeling is used to probe the biochemical transformations and modifications that occur in a cell. This is accomplished by using chemical analogs that mimic the structure of natural biomolecules. Cells utilize analogs in their endogenous biochemical processes, producing compounds that are labeled. The label allows for the incorporation of detection and affinity tags, which can then be used to elucidate metabolic pathways using other biochemical analytical techniques, such as SDS-PAGE...
FAQs
Insulin sensitivity helps determine how effectively cells respond to insulin and take up nutrients from the circulation. When this response changes, nutrient absorption and storage may no longer match the body's energy demands, making glucose regulation harder to maintain. Researchers therefore treat insulin sensitivity as a central biological indicator when examining metabolic health and evaluating changes associated with interventions.
Coordination among the liver, muscle, and adipose tissue allows metabolism to adjust as energy demands change. These organs and tissues must also remain aligned with cellular insulin responses and with the absorption and storage of nutrients. Studying this coordination helps biologists connect whole-body measurements with the underlying tissue-level processes that support metabolic stability.
Homeostasis becomes vulnerable when glucose, lipid, blood pressure, or insulin-related regulation is disrupted. In biology, that disruption provides a framework for examining why metabolic health is associated with obesity, type 2 diabetes, cardiovascular disease, and other conditions. The value of this framework is its focus on interacting physiological processes rather than on a single measurement alone.
Researchers commonly examine blood glucose, triglycerides, blood pressure, and insulin sensitivity. Each measurement represents a different aspect of regulation, including glucose control, lipid status, pressure regulation, or cellular responsiveness to insulin. Considering these indicators together supports risk assessment and gives studies several ways to evaluate whether metabolic regulation is changing.
These interventions can be studied by tracking the same metabolic indicators used for assessment, including blood glucose, triglycerides, blood pressure, and insulin sensitivity. Comparing how those measures change provides evidence about whether an intervention affects energy regulation and homeostasis. This approach connects practical changes in diet, activity, or treatment with measurable biological outcomes.
It provides a biological context for linking cellular and tissue processes to major health conditions. Researchers can use the topic to investigate how altered insulin responses, nutrient handling, or organ-level metabolic adjustment relate to obesity, type 2 diabetes, cardiovascular disease, and other disorders. It also supports evaluation of strategies intended to improve regulation through nutrition, activity, or treatment.