Mouse Head Fixation
Mouse Head Fixation - Related Videos
02:34
Mouse Headpost Implantation: A Method for Head Fixation in Rodents
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2023
This video shows a headpost implantation surgery in murine model. The headpost is used not only to head-fix and therefore restrain the mouse during experimentation, but also to securely attach a head device in freely moving animals.
07:51
Acrylic Resin Molding Based Head Fixation Technique in Rodents
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Cited by 4 •
2016
Traditional head fixation techniques have used metallic frames attached on the skull as an interface for head fixation apparatus. This protocol demonstrates a frameless, acrylic resin molding based head fixation technique for behavioral tasks in rodents.
06:57
Instillation and Fixation Methods Useful in Mouse Lung Cancer Research
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Cited by 48 •
2015
The goal of this paper is to describe simple methods that will greatly aid in the setup and analysis of mouse lungs with lung cancer or other pathologies. We present 3 protocols to simply and reliably carry out lung instillations, fixation, and lung volume measurements.
04:13
Modeling Repetitive Concussive Head Injuries in a Mouse Model
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2025
Source: Yang, Z., et.al. A Repetitive Concussive Head Injury Model in Mice. J. Vis. Exp. (2016).This video demonstrates the induction of repetitive concussive head injuries in a mouse using an electromagnetic impact device. The procedure involves positioning the impact tip between the interfrontal and lambdoid sutures on the skull of an anesthetized mouse and using a probe tip to precisely set the impact depth. The impact is delivered at a controlled velocity and depth to simulate mild...
07:10
Modified Long Head of Biceps Tendon Rerouting and Fixation as Partial Capsular Reconstruction for Massive Irreparable Rotator Cuff Tears
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2026
We propose a technical modification for capsular reconstruction that utilizes arthroscopic rerouting and fixation of the long head of the biceps tendon to enhance the repair of massive irreparable rotator cuff tears.
FAQs
The headpost creates a stable mechanical reference between the mouse’s skull and the experimental apparatus. By limiting relative head movement, it helps keep the animal’s position consistent while researchers record neural activity or observe behavior. That stability is especially important when measurements depend on precise alignment, such as microscopy, sensory stimulation, or eye and movement measurements.
Mouse Head Fixation can support several measurement modalities because the same stabilized position can be paired with different experimental systems. Researchers may combine the preparation with microscopy, electrophysiological recording, sensory stimulation, or measurements of the eyes and other movements. The chosen modality determines whether the primary readout is brain activity, a stimulation response, or behavior.
Behavioral training gives the mouse a structured task in which neural signals and actions can be examined together. Head stabilization limits movement, but training provides the behavioral context needed to study relationships involving perception, decision-making, and motor control. Appropriate welfare procedures accompany the preparation during this research use.
A typical preparation secures a lightweight headpost or similar implant to the skull, positions the mouse relative to the experimental apparatus, and attaches the implant to a fixed support. Researchers then use behavioral training to establish the task conditions. Appropriate welfare procedures are part of the preparation and experimental process.
The central components are a lightweight headpost or similar skull implant and a fixed support that holds the head relative to the apparatus. This arrangement can be integrated with microscopy, electrophysiological recording, sensory stimulation, or eye and movement measurements. Consistent positioning provides the controlled conditions needed for these experimental readouts.
Researchers use the preparation when they need to relate neural signals to behavior under reproducible conditions. It is relevant to studies of perception, decision-making, and motor control, especially when experiments require microscopy, electrophysiology, sensory stimulation, or precise eye and movement measurements. The approach therefore connects brain activity with observable task-related behavior.