Congenital Anomalies
Congenital Anomalies - Related Videos
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
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Cited by 40 •
2014
This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.
03:40
Three-Dimensional Printing of a Complex Aortic Anomaly
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Cited by 3 •
2018
Here, we present a protocol to use three dimensional printed models for pre-operative planning and intra-operative reorganization of complicated vascular locations when handling a congenital aortic anomaly.
02:37
Robot-Assisted Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma
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Cited by 3 •
2023
This protocol describes the removal of congenital cholesteatoma using minimally invasive transcanal endoscopic ear surgery with a two-handed approach and a robotic endoscope holder.
08:28
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
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Cited by 4 •
2020
In this protocol, we describe procedures to qualitatively and quantitatively analyze developmental phenotypes in mice associated with congenital heart defects.
03:47
Methylene Blue Dye Injection in Mouse Embryonic Urinary Tract: A Method To Assess the Congenital Obstruction in the Urinary Tract
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2025
In this video, we administer methylene blue dye injection into the urinary tract of a perinatal embryonic mouse to assess congenital anomalies related to urinary tract obstruction.
FAQs
During prenatal development, embryonic signaling helps coordinate cell differentiation, tissue formation, and organ development. If these developmental processes are disrupted, cells may receive altered instructions or fail to organize normally, producing structural or functional differences. Studying these connections allows biologists to relate specific developmental events to later health outcomes and to identify stages at which abnormalities may arise.
A congenital anomaly may reflect genetic changes, chromosomal abnormalities, environmental exposures, maternal conditions, or an interaction among these influences. This multifactorial pattern means that one observed outcome may not have a single identifiable cause. Some cases remain unexplained, so biological investigation must consider both inherited or cellular mechanisms and conditions affecting prenatal development.
Genetic changes and chromosomal abnormalities represent distinct types of biological disruption, although both can interfere with prenatal development. Their effects may alter developmental processes that guide cell differentiation, tissue formation, or organ development. Separating these categories helps researchers interpret genetic findings more carefully and connect changes in biological information with particular health outcomes.
The consequences of disruption depend on which developmental processes are affected during prenatal development. Embryonic signaling, cell differentiation, tissue formation, and organ development occur as connected biological activities, so interference with one process may influence later outcomes. This developmental perspective helps researchers explain why anomalies can involve one organ system or several and why effects vary among individuals.
Genetic analysis and prenatal imaging provide complementary information. Genetic analysis can support investigation of biological factors associated with an anomaly, while prenatal imaging can assist earlier detection of developmental differences. Together with developmental research, these approaches help researchers and clinicians assess possible risks, examine prenatal findings, and plan appropriate care for affected individuals.
Developmental research connects embryonic signaling, cell differentiation, tissue formation, and organ development with health outcomes. Those connections can improve understanding of how genetic, chromosomal, environmental, and maternal influences affect prenatal development. The resulting knowledge supports risk assessment and prevention strategies, while also helping interpret why some anomalies remain unexplained.
Research on congenital anomalies can contribute to earlier detection, risk assessment, prevention strategies, and care for affected individuals. Genetic analysis and prenatal imaging provide information that may guide evaluation, while developmental biology explains how disrupted processes relate to health outcomes. This combination supports more informed decisions about monitoring and care without assuming that every case has an identifiable cause.