Neuro-cardiac Safety
Neuro-cardiac Safety - Related Videos
10:39
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
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Cited by 38 •
2017
Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.
09:36
Electrical Safety Precautions and Basic Equipment
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. Electric machines and power electronics experiments involve electrical currents, voltages, power, and energy quantities that should be handled with extreme diligence and care. These may include three-phase AC voltage (208 V, 230 V, or 480 V), up to 250 V DC voltages, and currents that can reach 10 A. Electrocution occurs when an electrical path is established through the body with very low currents...
04:53
Electrical Safety
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2023
Robert M. Rioux & Suprita Jharimune, Pennsylvania State University, University Park, PA Among the many hazards present in the laboratory, electrical hazards are one of the most common we must be cognizant of since most of the laboratory equipment we use requires electricity for operation. Improper handling or operation of electrical devices might lead to electric shock with the potential risk of injury or even death. Electric sparks can lead to fire or explosion (since many flammable...
09:44
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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Cited by 10 •
2016
This article reports the development of a neuro-rehabilitation approach, "constraint-induced sound therapy (CIST)" for sudden sensorineural hearing loss. The aim of CIST is to prevent maladaptive cortical reorganization by using an enriched acoustic environment. CIST represents a safe, easy, inexpensive, and effective approach to treat sudden sensorineural hearing loss.
02:45
Multisystem Monitoring in Rabbit Model: A Method to Assess Neuro-Cardiac and Respiratory Parameters to Study the Oral Drug-induced Triggers for Arrhythmia and Seizures
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2025
In this video, we describe simultaneous recording of video, EEG, ECG and respiratory cues in a rabbit model in response to orally administered drug to understand the sequence of events leading to seizure. The model can be used for testing potential drugs for their neuro-cardiac safety.
FAQs
Autonomic signaling helps regulate heart rate, cardiac conduction, vascular tone, and blood pressure. A biological intervention that changes neurotransmitter signaling can therefore affect several cardiovascular functions at once, rather than producing an isolated change in the heart. Evaluating these linked responses helps reveal whether altered nervous-system activity could contribute to abnormal rhythm, pressure, or vascular control.
Ion channels contribute to electrical activity in cardiac cells, so compounds that modify their activity may disturb cardiac conduction or repolarization. Repolarization is the electrical recovery that prepares the heart for its next cycle. Monitoring these effects is important because altered electrical recovery can signal a potential risk of abnormal cardiac rhythms during therapeutic development.
Changes in neurotransmitter signaling can influence autonomic control of the heart and blood vessels. Because this control affects heart rate, vascular tone, and blood pressure, neurological activity may be accompanied by cardiovascular changes. Considering both systems allows investigators to relate an observed neurological effect to possible alterations in cardiac or vascular function.
A heart-focused evaluation may miss risks that arise through nervous-system regulation. The autonomic nervous system links neurological signaling with cardiac conduction, vascular tone, and blood pressure, while interventions may act through neurotransmitters or ion channels. Combining neurological and cardiovascular endpoints provides a broader view of how an intervention affects connected physiological functions.
Relevant endpoints include heart rate, cardiac conduction, vascular tone, blood pressure, and cardiac repolarization, together with neurological effects such as impaired reflexes. Investigators also look for outcomes including arrhythmias and abnormal blood pressure. Examining these measures together can show whether a biological intervention produces isolated, linked, or simultaneous effects across the two systems.
The assessment combines neurological and cardiovascular observations during preclinical testing and clinical risk evaluation. Investigators use the resulting information to identify adverse effects involving arrhythmias, abnormal blood pressure, impaired reflexes, or related physiological changes. These findings can guide safer therapeutic design and help define risks that warrant attention as development progresses.
It is especially relevant when a drug, therapy, or biological intervention may alter autonomic regulation, neurotransmitter signaling, ion-channel activity, or cardiac repolarization. In such cases, effects in one system may influence the other through their physiological connection. Integrating endpoints supports interpretation of safety findings across experimental and clinical settings rather than treating each system separately.