Seizure Monitoring

Seizure monitoring is the systematic observation and recording of seizures and related brain activity to identify abnormal neural patterns, characterize events, and guide diagnosis. It commonly combines clinical observation with electroencephalography (EEG), which detects electrical activity through electrodes placed on the scalp; video-EEG can correlate behavioral changes with concurrent brain signals. In biology and neuroscience, monitoring helps distinguish epileptic seizures from similar-appearing events, classify seizure types, evaluate treatment responses, and support research on neural circuit dysfunction. Continuous or long-term monitoring can also capture infrequent episodes, improving the evidence available for clinical decision-making and investigations of brain function.

Seizure Monitoring - Related Videos

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JoVE EoE - Neuropathology

Triggering and Monitoring Heat-Induced Seizures in a Transgenic Mouse Model

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2025

This video demonstrates the procedure to induce heat-induced seizures in a transgenic mouse with epilepsy-related gene mutations by gradually increasing body temperature in a controlled chamber. This protocol is used to study seizure mechanisms and potential therapies for epilepsy.

Monitoring the Brain Cortex with a Multi-Electrode Array in Response to Seizure-Inducing Agents

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2025

In this video, the effects of transcranial direct-current stimulation (tDCS) on brain slices containing the anterior cingulate cortex (ACC) and thalamus regions are investigated, using a multi-electrode array (MEA) to measure electric signals. By delivering electric pulses and infusing seizure-inducing drugs, the study investigates the ACC response to seizures.

Monitoring Seizure-Induced Neural Electrical Activity in Brain Slices Using Microelectrode Arrays

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2025

This protocol involves using a microelectrode array (MEA) to record electrical activity in a brain slice exposed to a seizure-inducing drug. The procedure includes positioning the brain slice in an MEA recording chamber, applying electrical stimulation to induce artificial seizures, and analyzing the resulting signals.

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

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Cited by 4 •

2017

Electroconvulsive seizure (ECS) is an experimental animal model of electroconvulsive therapy for severe depression. ECS globally stimulates activity in the hippocampus, leading to synaptogenesis and synaptic plasticity. Here, we describe methods for ECS induction in rats and for subcellular fractionation of their hippocampi to examine seizure-induced changes in synaptic proteins.

Multisystem Monitoring of Epileptic Abnormalities in Rabbit: A Method for Simultaneous Video EEG, ECG, Capnography, and Oximetry Recording During Induced Seizures

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2025

In this video, we demonstrate a multisystem monitoring method to evaluate neurological and cardiorespiratory abnormalities during intravenous injection of a seizure-inducing drug. The simultaneous monitoring of video EEG, ECG, oximetry, and capnography parameters helps to understand the real-time physiological changes associated with epileptic seizures.

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