Stereotactic Surgery
Stereotactic Surgery - Related Videos
10:35
Stereotactic Radiosurgery for Gynecologic Cancer
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Cited by 14 •
2012
Stereotactic body radiotherapy (SBRT) involves image-guided, ablative radiation delivered to cancer targets refractory to chemotherapy or to conventional radiation treatment. The robotic-armed Cyberknife SBRT system, using sophisticated target localization, delivers hypofractionated radiation doses capable of sterilizing cancer targets. This article will consider new therapeutic roles of SBRT for gynecological cancers.
00:08
Survivable Stereotaxic Surgery in Rodents
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Cited by 50 •
2008
The monitoring of extracellular neurotransmitter levels in distinct brain regions of freely moving animals offers insights on the link between neurotransmitter release and behavior. In vivo microdialysis coupled with electrochemical detection provides excellent anatomical and chemical resolution; and information on how basal neurotransmission is altered by pharmacological or physiological manipulations.
08:28
Rodent Stereotaxic Surgery
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2023
Stereotaxic (or stereotactic) surgery is a method used to manipulate the brain of living animals. This technique allows researchers to accurately target deep structures within the brain through the use of a stereotaxic atlas, which provides the 3D coordinates of each area with respect to anatomical landmarks on the skull. After the skull is exposed, anesthetized animals are mounted on a specialized instrument known as a stereotaxic frame, which enables the precise placement of experimental...
05:08
A Stereotactically Guided Ablation Technique for Auditory Cortex Removal in Rats
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2025
This video demonstrates a stereotactically-guided surgical procedure for ablating the auditory cortex in a rat. The steps include identifying anatomical landmarks in an anesthetized rat secured in a stereotactic frame, creating a window on the skull above the auditory cortex, aspirating the cortical layers, and providing post-operative care to assess the impact of the ablation on sound processing.
10:52
Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
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Cited by 42 •
2012
We describe an integrated method for the precise, stereotactic implantation of human glioblastoma multiforme cells into the brains of nude mice and subsequent serial in vivo imaging to monitor growth and response to treatment of the resultant xenografts.
FAQs
Three-dimensional coordinates convert the intended target into a spatial reference that can be matched to the patient’s anatomy. Imaging supplies the anatomical map, while the frame or frameless navigation system preserves the relationship between that map and the planned instrument path. This lets the surgeon account for target position during access rather than relying on a visual estimate alone.
Imaging alignment is central because the target is identified on magnetic resonance imaging or computed tomography before an instrument or therapeutic energy is directed. Registering those images with the guidance system links visible anatomy to the operative trajectory. The result is targeted access to a defined location, with the technique designed to limit injury to nearby tissue.
The planned trajectory matters as much as the endpoint. Stereotactic surgery allows the surgeon to account for both the target’s location and the route taken to reach it, helping keep the intervention focused on the intended region. This principle is especially relevant when a procedure must reach a deep brain site while limiting effects on surrounding structures.
The biological goal determines whether the procedure supports a brain biopsy, lesion ablation, electrode placement, or targeted treatment delivery. A biopsy uses the guidance system to reach a defined site for diagnostic investigation, whereas ablation applies therapeutic energy and electrode placement enables targeted neural intervention. These applications use the same precision framework for different outcomes.
A typical workflow identifies a target, obtains magnetic resonance or computed tomography images, and aligns those data with either a stereotactic frame or frameless navigation system. The surgeon then uses the registered anatomy to account for the target’s position and guide an instrument, electrode, therapeutic energy, or delivered treatment along the intended path.
In biology and neuroscience, precise targeting allows investigators to connect specific brain regions with neural circuits, disease mechanisms, and region-specific function. Electrode placement can support targeted study of neural sites, while biopsies, lesion interventions, and treatment delivery provide ways to examine or affect defined locations. The method therefore links anatomical precision with biological questions about localized brain activity.