Stratified Epithelium
Stratified Epithelium - Related Videos
01:29
Classification of Epithelial Tissues: Stratified Epithelium
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2025
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
01:16
Stratified Sampling Method
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2023
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest. To choose a stratified sample, divide the population into groups called strata and then take a...
10:44
Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
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Cited by 7 •
2013
Primary disassociated embryonic hippocampal neuronal cultures are useful for investigating the signaling mechanisms involved in neuron death. Sexing the embryos before the isolation and dissociation of the hippocampus allows the preparation of separate male and female cultures, which enables the researcher to identify and investigate sex-specific cell signaling.
03:38
Isolation of Circumvallate Papillae (CVP) Epithelium from Mouse Model: An Enzymatic Procedure to Separate CVP Epithelium from Mouse Tongue
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2025
In this video, we describe the isolation of circumvallate papillae (CVP) epithelium from a murine tongue.
08:27
Multielectrode Array Recordings of the Vomeronasal Epithelium
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Cited by 14 •
2010
Multielectrode array (MEA) recordings provide a method for studying the electrical activity of large populations of neurons. Here, we present the details of a MEA preparation to record from the mouse vomeronasal epithelium while simultaneously stimulating the tissue.
FAQs
Basal cells maintain the tissue by attaching to the basement membrane and dividing to replace cells lost from the exposed surface. As newly produced cells move outward, they contribute to the progressive organization of the layers. This renewal mechanism allows the epithelium to preserve a protective covering despite continual abrasion, chemical stress, and possible pathogen exposure.
Keratin accumulation creates a specialized surface in keratinized stratified squamous epithelium, such as that found in skin. The process accompanies changes in superficial cells as they move away from the basal layer, strengthening protection where exposure is substantial. By contrast, nonkeratinized tissue in the mouth and esophagus provides a different surface arrangement suited to those locations.
Cells in deeper and more superficial layers do not remain identical as they move through the tissue. Their shapes change progressively toward the exposed surface, producing an organized arrangement rather than a uniform sheet. This layered progression helps the epithelium combine basal replacement with a specialized outer barrier that resists mechanical and chemical challenges.
A useful examination focuses on the number and organization of cell layers, the attachment of basal cells to the basement membrane, and changes in cell shape toward the surface. Investigators can also determine whether superficial cells accumulate keratin. These features help relate tissue structure to barrier function, renewal, wound healing, and disease-related changes.
Keratinized stratified squamous epithelium occurs in skin, where surface keratin contributes to protection. Nonkeratinized stratified squamous epithelium lines the mouth and esophagus, which are also exposed to substantial mechanical stress but have a different surface organization. Other stratified forms occur in selected ducts, where multiple layers help provide protection in localized passages.
Its basal cells provide a source of replacement cells, while the layered structure establishes a barrier between underlying tissues and the external or luminal environment. Studying how these features are maintained helps explain tissue renewal and wound healing. Changes in layer organization, cell shape, or surface specialization can also provide context for disease-related tissue changes.