Tissue Organization
Tissue Organization - Related Videos
08:45
Whole Organ Tissue Culture
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2023
Whole organs can be cultured ex vivo using specialized bioreactors with the goal of repairing or replacing entire organs. This method uses a donor organ that is stripped of all cells, leaving behind the three-dimensional structure, which is then repopulated with new cells. This video demonstrates the whole organ culture of lungs and shows how a dynamic culture that mimics the mechanical stimulation in the body is needed to induce native tissue properties.
01:19
Cadherins in Tissue Organization
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2023
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues. Cell Sorting During Development Cell sorting plays an...
11:17
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
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Cited by 5 •
2014
The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.
13:52
Studying the Supramolecular Organization of Photosynthetic Membranes within Freeze-fractured Leaf Tissues by Cryo-scanning Electron Microscopy
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Cited by 19 •
2016
Here we describe a procedure for studying freeze-fractured plant tissues. High-pressure frozen leaf samples are freeze-fractured and double-layer coated, yielding well preserved frozen-hydrated samples that are imaged using the cryo-scanning electron microscope at high magnifications with minimal beam damage.
10:17
Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
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Cited by 18 •
2014
Laser-induced breakdown spectroscopy performed on thin organ and tumor tissue successfully detected natural elements and artificially injected gadolinium (Gd), issued from Gd-based nanoparticles. Images of chemical elements reached a resolution of 100 μm and quantitative sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes its potential to provide multiple images of a same biological tissue.
FAQs
Cell adhesion links neighboring cells and helps maintain their relative positions, while communication coordinates their behavior across the tissue. Differentiation gives cells specialized properties, allowing them to contribute distinct functions within a shared structure. Together, these processes create coordinated arrangements rather than isolated cell populations, supporting functional layers, compartments, and networks in organs.
The extracellular matrix provides more than mechanical support. Its interactions with cells help guide position and polarity, meaning the directional organization of a cell within its surroundings. It also influences how cells respond to local signals. These functions allow tissues to maintain architecture while coordinating cellular behavior with the surrounding structural environment.
Remodeling allows tissue architecture to change during development, repair damage, and adapt to changing conditions. It does not simply preserve an existing arrangement; it adjusts relationships among cells and extracellular materials as biological demands change. This flexibility helps tissues remain functional over time, while abnormal remodeling can contribute to disrupted architecture and disease.
A useful analysis considers how cells are positioned, how they interact with one another and with extracellular materials, and whether the tissue forms recognizable layers, compartments, or networks. Researchers can then relate structural patterns to shared biological functions. Examining these connections helps explain how local cellular arrangements contribute to the performance of an entire organ.
The same organizing principles support different biological arrangements across tissue types. Epithelial tissues form functional barriers and layers, connective tissues provide structural relationships through cells and extracellular materials, muscle tissues support coordinated functional organization, and nervous tissues form communication networks. Comparing these patterns shows how cellular arrangement is linked to the specialized role of each tissue.
When adhesion, communication, differentiation, extracellular-matrix interactions, or remodeling become improperly coordinated, cells may occupy abnormal positions or lose appropriate relationships with neighboring structures. The resulting disruption can affect tissue layers, compartments, or networks. Studying these architectural changes connects cellular behavior with developmental abnormalities and disease-related loss of normal organ function.