Vascular Physiology
Vascular Physiology - Related Videos
07:26
Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research
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Cited by 9 •
2023
This protocol presents a physiologically relevant tumor-on-a-chip model to perform high-throughput basic and translational human cancer research, advancing drug screening, disease modeling, and personalized medicine approaches with a description of loading, maintenance, and evaluation procedures.
07:30
In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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Cited by 6 •
2015
This protocol replicates physiological or pathological blood flow in vitro to aid in determining cell response in disease pathologies. By introducing a pressure damping chamber downstream of a blood pump, blood flow across the vasculature can be recapitulated and imposed on a monolayer of vascular endothelium or a mimetic co-culture.
05:33
Physiology of the Circulatory System - Concepts
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2019
Homeostasis Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal conditions. To maintain homeostasis, organisms have developed structures with distinct functions. Physiology is the...
10:28
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
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2017
This manuscript describes in vitro video microscopy protocols for evaluating vascular function in rat cerebral resistance arteries. The manuscript also describes techniques for evaluating microvessel density with fluorescently labeled lectin and tissue perfusion using Laser Doppler Flowmetry.
07:00
The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity
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Cited by 20 •
2012
An ex vivo preparation is described for isolation of the largest gracilis muscle resistance arterioles for interrogation of both vascular responses to vasoactive stimuli and the assessment of basic structural properties via passive wall mechanics.
FAQs
Pressure gradients provide the driving force for blood movement, while vascular resistance determines how strongly vessels oppose that movement. Changes in vessel diameter can therefore redistribute flow between tissues by altering resistance. This relationship helps explain how circulation adjusts to changing physiological demands and how abnormal resistance can contribute to elevated blood pressure or inadequate tissue perfusion.
Vessel wall elasticity allows vessels to respond to changing internal pressure, while smooth muscle activity adjusts vessel tone and diameter. Together, these properties help maintain appropriate circulation as conditions change. Their coordinated action influences both blood pressure and the amount of blood reaching tissues, making them important variables in studies of cardiovascular function and vascular disorders.
Endothelial signals provide regulatory communication between the vessel lining and the surrounding smooth muscle. By influencing smooth muscle activity, these signals help adjust vessel diameter and coordinate local circulation with tissue needs. Their role connects the condition of the vessel wall to broader changes in perfusion and blood pressure, making endothelial regulation an important mechanism in vascular physiology.
During exercise or inflammation, tissues and vessels face changing demands that require circulation to be adjusted. Vascular physiology examines how pressure, vessel diameter, wall properties, endothelial signals, and smooth muscle activity work together under these conditions. Studying these responses helps researchers understand how the circulatory system preserves tissue perfusion while adapting to physiological or inflammatory challenges.
The framework links abnormal blood pressure or inadequate tissue perfusion to changes in pressure gradients, vascular resistance, vessel elasticity, diameter, and regulatory signaling. This allows researchers and clinicians to examine cardiovascular dysfunction through interacting vascular mechanisms rather than isolated measurements. Such interpretation supports the study of disease processes and clarifies how altered vessel behavior can affect tissue homeostasis.
Vascular physiology is relevant whenever researchers or clinicians need to evaluate cardiovascular function, circulation, or blood pressure regulation. It provides principles for interpreting how vessels respond to changing conditions and for examining factors that influence tissue perfusion. The same knowledge supports development of therapies designed to modify vessel tone or blood pressure and helps investigate cardiovascular disease.