Intra-uterine Injection
Intra-uterine Injection - Related Videos
04:20
Intra-uterine Cancer Cell Injection: A Technique to Deliver Cancer Cells for Establishing Intra-peritoneal Ovarian Cancer Mouse Model
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2023
In this video, we demonstrate intra-uterine injection of ovarian cancer cells in a mouse model. This orthotopic murine model helps us to non-invasively monitor tumor growth and evaluate the efficacy of new therapies for the prevention and treatment of recurrent ovarian cancer.
08:30
Intra-articular Shoulder Injection for Reduction Following Shoulder Dislocation
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2023
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA The anterior shoulder dislocation is one of the most common joint dislocations seen in emergency settings. In anterior shoulder dislocation, the humeral head is displaced out of the glenohumeral joint in front of the scapular glenoid, resulting in a loss of the articulation between the arm and the rest of the shoulder. This can be caused by a fall onto an abducted, extended, and externally...
09:06
Intra-lymph Node Injection of Biodegradable Polymer Particles
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Cited by 45 •
2014
Lymph nodes are the immunological tissues that orchestrate immune response and are a critical target for vaccines. Biomaterials have been employed to better target lymph nodes and to control delivery of antigens or adjuvants. This paper describes a technique combining these ideas to inject biocompatible polymer particles into lymph nodes.
07:00
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Cited by 43 •
2016
This manuscript provides the detailed procedure of intra-iliac artery (IIA) injection, a technique to deliver cancer cells specifically to hind limb tissues including bones to establish experimental bone metastases. Although initially established with breast tumor models, this protocol can be easily extended to other cancer types.
10:25
In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
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Cited by 2 •
2015
This manuscript describes a technique for visualization of the developing vasculature. Here we utilized in utero intra-cardiac FITC-labeled tomato lectin microinjections on mouse embryos. Using this technique, we delineate the perfused and unperfused vessels throughout the embryonic kidney.
FAQs
Localized delivery concentrates an experimental material at the endometrial lining, where researchers can examine uterine responses directly. It also helps limit exposure to other tissues, creating a controlled setting for studying local effects. In cancer research, this distinction supports evaluation of uterine tumor development and treatment activity without relying only on responses occurring outside the uterus.
Material placed in the uterine cavity contacts the endometrial lining, allowing researchers to observe localized biological responses or tumor formation under controlled conditions. The resulting model can reveal how cancer cells behave within uterine tissue and can support studies of tumor development. This local interaction is central to interpreting disease-related changes in the uterus.
The technique places a drug or other experimental treatment near the uterine tissue being studied. Researchers can therefore examine treatment response in a localized uterine setting while limiting exposure to other tissues. In endometrial cancer research, this helps connect a therapy's local effects with tumor behavior and supports investigation of mechanisms associated with treatment response.
A study begins by selecting the cells, drug, or other experimental material and preparing a measured suspension. The material is then introduced into the uterine cavity through the cervix or uterine wall. Researchers subsequently examine localized responses, tumor formation, cancer-cell behavior, or treatment response, depending on the experimental objective and model design.
Intra-uterine injection can support several related questions: how uterine tumors develop, how cancer cells behave in the uterine environment, and how tumors respond to targeted treatments. Because the material is delivered locally, investigators can focus observations on uterine biology and disease. The approach also supports studies of mechanisms underlying endometrial cancer.
Outcomes may include evidence of localized uterine responses, tumor formation, changes in cancer-cell behavior, or differences in treatment response. These observations help researchers evaluate experimental materials in a controlled uterine context. In cancer research, the findings can contribute to tumor-model development and to understanding processes involved in endometrial cancer progression and therapy.