Tumor Metabolism
Tumor Metabolism - Related Videos
06:50
Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
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Cited by 1 •
2025
Here, we establish a metabolic profiling platform integrating three-dimensional (3D) glioma spheroids and imaging-based normalization via extracellular flux analysis. This approach enables more accurate assessment of tumor metabolic responses to drug treatments and provides insights into potential mechanisms of resistance.
05:39
Extracellular Flux Assay in 3D Spheroids: A Method for Measuring the Metabolic Activity of Pancreatic Tumor Spheroids
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2023
This protocol describes the technique for performing extracellular flux assay on 3D spheroids generated from the co-culture of pancreatic cancer cells (Patu8902) and activated pancreatic fibroblasts (PS1) to measure the two major energy-producing pathways, glycolysis and mitochondrial respiration.
05:27
FDG Based PET/CT Scan: A Method of Using Radiotracer for Non-invasive Imaging of Tumor Metabolism
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2023
This article describes multimodality imaging of cancerous tissues with PET and CT diagnostic imaging by using a radiotracer 18F-FDG. Cancerous tissue with high glycolytic activity uptakes more 18F-FDG.
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
FAQs
Redirected nutrients support the synthesis of nucleotides, lipids, and proteins needed to build new cellular material. This allocation allows tumor cells to connect nutrient use with continued growth rather than treating metabolism as an energy-only process. Studying these biosynthetic demands helps researchers identify which metabolic pathways tumors may depend on most strongly.
Oncogenic signaling can increase glucose uptake and glycolysis, while hypoxia can reinforce this shift within the tumor environment. Together, these influences change how glucose is processed and can increase lactate production even when oxygen is present. Their effects help explain why metabolic behavior varies with both cancer-cell signaling and local tumor conditions.
Lactate production despite available oxygen indicates that glucose processing has been reorganized rather than governed solely by oxygen availability. This pattern provides a measurable feature of altered tumor metabolism and contributes to the surrounding metabolic environment. Because these changes can interact with tumor behavior and treatment response, lactate-related metabolism is relevant in cancer research.
Local conditions within a tumor influence how cancer cells obtain and use nutrients. Hypoxia is one important condition, and metabolic changes can in turn affect interactions with the surrounding microenvironment. These relationships are significant because altered metabolism may support invasion, treatment resistance, and immune evasion, linking cellular nutrient use with broader tumor progression.
Researchers investigate it through metabolic profiling and by examining relevant enzymes, metabolites, and nutrient dependencies. These approaches can characterize how tumor cells use available nutrients and reveal pathway changes associated with growth or adaptation. The resulting information supports studies of tumor biology while helping prioritize metabolic features for biomarker discovery or therapeutic development.
Metabolic profiling can identify patterns in nutrient use and pathway activity that distinguish important features of tumor biology. When combined with analysis of enzymes, metabolites, and nutrient dependencies, it may reveal biomarkers or expose metabolic requirements that are more prominent in tumors. Such findings help connect measurable metabolic states with research questions about progression and treatment.
Therapeutic research can target metabolic requirements that tumors rely on for growth or survival. Strategies described in cancer research include disrupting glycolysis or exploiting other tumor-specific metabolic vulnerabilities. These approaches are designed to interfere with the altered nutrient-use patterns of cancer cells, while metabolic studies help identify which pathways or dependencies are suitable for further evaluation.