Oil-in-water Nanoemulsion
Oil-in-water Nanoemulsion - Related Videos
01:50
Preparation of a Nanoemulsion Adjuvant Vaccine
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2025
This video demonstrates the production of nanoemulsion tumor vaccines. The stable oil reservoir depots carrying synthetic peptides and adjuvants are produced by low-energy nanoemulsion, offering significant promise for tumor immunotherapy.
11:26
Water in Oil Emulsions: A New System for Assembling Water-soluble Chlorophyll-binding Proteins with Hydrophobic Pigments
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Cited by 2 •
2016
This manuscript describes a simple and high-throughput method for assembling water-soluble proteins with hydrophobic pigments that is based on water-in-oil emulsions. We demonstrate the effectiveness of the method in the assembly of native chlorophylls with four variants of recombinant water-soluble-chlorophyll binding proteins (WSCPs) of Brassica plants expressed in E. coli.
05:43
Preparation of Giant Vesicles Encapsulating Microspheres by Centrifugation of a Water-in-oil Emulsion
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Cited by 13 •
2017
Giant vesicles containing highly packed micrometer-sized components are useful cell models. The water-in-oil emulsion centrifugation method is a simple, powerful tool for the preparation of giant vesicles with encapsulated materials.
08:17
Chemical Analysis of Water-accommodated Fractions of Crude Oil Spills Using TIMS-FT-ICR MS
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Cited by 10 •
2017
The low-energy water-accommodated fraction (LEWAF) of crude oil is a challenging system to analyze, because over time, this complex mixture undergoes chemical transformations. This protocol illustrates methods for the preparation of the LEWAF sample and for performing photo-irradiation and chemical analysis by trapped ion mobility spectrometry–FT-ICR MS.
13:19
Enhanced Oil Recovery using a Combination of Biosurfactants
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Cited by 2 •
2022
We illustrate the methods involved in screening and identification of the biosurfactant producing microbes. Methods for chromatographic characterization and chemical identification of the biosurfactants, determining the industrial applicability of the biosurfactant in enhancing residual oil recovery are also presented.
FAQs
Surfactants lower the interfacial tension between the oil and aqueous phases, making droplet formation easier during processing. They then arrange protective layers around the oil droplets, which helps limit coalescence, or the merging of neighboring droplets. This interfacial organization is central to maintaining dispersion and influences how the formulation behaves in pharmaceutical, food, cosmetic, and materials applications.
Ultrasonication and homogenization supply high energy that breaks larger oil domains into smaller droplets. Reducing droplet size supports a more finely dispersed system and, together with the surfactant layer, helps limit coalescence. The selected energy-based method therefore affects the resulting droplet population and can influence the formulation’s stability, appearance, and functional performance.
Droplet size, composition, and interfacial structure are key variables. Droplet size affects how finely the oil phase is dispersed, while composition determines the materials present in both phases and at their boundary. The interfacial structure created by emulsifiers further influences resistance to coalescence. Together, these features shape stability, visual appearance, and the system’s practical performance.
Preparation begins by bringing the immiscible oil and aqueous phases together with a suitable surfactant or emulsifier. High-energy processing, such as ultrasonication or homogenization, then reduces the oil domains to nanoscale droplets. The resulting formulation is evaluated through its droplet size, composition, and interfacial structure because these characteristics determine whether the dispersion achieves the intended stability and performance.
Researchers may select this platform when a compound has poor water solubility or needs improved dispersion within an aqueous formulation. The oil droplets provide a dispersed environment that can support delivery of such compounds, while the aqueous continuous phase supports handling in water-based systems. This makes the approach relevant to pharmaceutical, food, cosmetic, and materials-science formulations.
Studying the system can show how droplet size, formulation composition, and interfacial organization affect the behavior of immiscible liquids. Researchers can relate these structural features to stability, appearance, dispersion, solubility, and delivery performance. In chemistry, this links molecularly controlled interfaces with macroscopic formulation outcomes and helps guide the design of systems for different application areas.