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Chapters
- 00:00Title
- 00:42Introduction
- 01:10Preparing the Operating Field
- 02:02Preparing and Intubation of Mice
- 03:25Ligation of the Transverse Aorta
- 06:31Confirmation of Successful Ligation of the Transverse Aorta
- 07:32Results of a Successful Transverse Aortic Constriction
- 08:02Conclusion
Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model to study mechanisms underlying cardiac hypertrophy and heart failure development. Here, we describe procedures to constrict the aorta to create a reproducible degree of cardiac hypertrophy in mice.
Tags
Transverse Aortic ConstrictionTACPressure OverloadCardiac HypertrophyHeart FailureMurine TAC ModelCardiovascular DiseasesSignaling ProcessesLeft Anterior Descending Coronary Artery OcclusionReproducible ModelGradual Time CourseSurgical ProcedureHigh Frequency Doppler ProbeBlood Flow VelocitiesLeft Ventricular Hypertrophy
