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Transverse Aortic Constriction in Mice
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Transverse Aortic Constriction in Mice

Article DOI: 10.3791/1729
April 21st, 2010 •
1, 1, 1,2
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM)

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April 21st, 2010

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model to study mechanisms underlying cardiac hypertrophy and heart failure development. Here, we describe procedures to constrict the aorta to create a reproducible degree of cardiac hypertrophy in mice.

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