Pharmacotherapy

Pharmacotherapy is the use of medicines to prevent, manage, or treat disease, making it a central component of clinical care. It works through interactions between drugs and biological targets, while pharmacokinetics and pharmacodynamics determine how a medicine is absorbed, distributed, metabolized, eliminated, and produces its effects. Clinicians select therapies by considering the patient’s condition, treatment goals, potential benefits, adverse effects, drug interactions, and individual factors that influence response. Applied across acute and chronic conditions, pharmacotherapy can relieve symptoms, control disease progression, prevent complications, and improve quality of life when integrated with monitoring and other forms of care.

Pharmacotherapy - Related Videos

Education

JoVE Core - Pharmacology

Psychosis: Goals of Pharmacotherapy

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2024

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

Diabetes: Management and Pharmacotherapy

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2024

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames. Insulin remains the cornerstone of treatment for most patients with type 1 and many...

Research

JoVE Journal - Neuroscience

Intracranial Pharmacotherapy and Pain Assays in Rodents

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2019

Here we present a protocol to perform intracranial pharmacological experiments followed by pain behavior assays in rodents. This protocol allows researchers to deliver molecular and cellular targets in the brain, for pharmacologic agents in the treatment of pain.

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

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Cited by 22 •

2019

Alcohol Use Disorder (AUD) is a major national health problem and the development of more effective treatments is required to offset the needs of this patient population. To this end, the following protocol utilizes two simple rodent drinking models to assess the preclinical efficacy of lead anti-alcohol compounds.

Research

JoVE Journal - Medicine
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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

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Cited by 97 •

2011

The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.

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