Respiratory Distress

Respiratory distress is a clinical condition in which breathing becomes difficult or inadequate to meet the body’s oxygen and carbon dioxide exchange needs, making rapid recognition essential. It can develop when airway obstruction, impaired lung expansion, inflammation, fluid accumulation, or weakened respiratory muscles increase the work of breathing and disrupt ventilation or oxygenation. Clinicians assess signs such as tachypnea, retractions, cyanosis, altered mental status, and abnormal breath sounds, alongside oxygen saturation and, when indicated, blood gas measurements. Identifying the underlying cause guides urgent interventions, including airway support, supplemental oxygen, bronchodilators, or treatment of infection and other contributing conditions.

Respiratory Distress - Related Videos

Research

JoVE Journal - Medicine

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)

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Cited by 21 •

2016

Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

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Cited by 4 •

2022

The present protocol describes a lung injury model in mice using oleic acid to mimic acute respiratory distress syndrome (ARDS). This model increases the inflammatory mediators on edema and decreases lung compliance. Oleic acid is used in the salt form (oleate) since this physiological form avoids the risk of embolism.

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

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Cited by 20 •

2018

In this article, we present a protocol to induce acute lung injury in pigs by central-venous injection of oleic acid. This is an established animal model for studying the acute respiratory distress syndrome (ARDS).

Education

JoVE Science Education - Clinical Skills

Respiratory Exam I: Inspection and Palpation

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2023

Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Disorders of the respiratory system with a chief complaint of shortness of breath are among the most common reasons for both outpatient and inpatient evaluation. The most obvious visible clue to a respiratory problem will be whether the patient is displaying any signs of respiratory distress, such as fast respiratory rate and/or cyanosis. In a clinical situation, this will always require...

The Application of Point-of-Care Ultrasonography (POCUS) in the Management of Acute Respiratory Distress Syndrome (ARDS) in the Intensive Care Unit

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2025

Here, we present a protocol for bedside POCUS application in ARDS management within the ICU. It details standardized techniques for lung, cardiac, diaphragm, venous, and gastric assessments to guide ventilation, predict weaning, and prevent complications.

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