Therapeutic Response Method

The Therapeutic Response Method is a clinical approach for assessing how a patient responds to an intervention and using that information to guide care. It involves establishing baseline findings, delivering a defined therapy, monitoring changes in symptoms or measurable clinical outcomes, and comparing those changes with the intended treatment response. This structured process helps clinicians determine whether a therapy is effective, ineffective, or requires modification, while supporting individualized treatment decisions. In clinical research, therapeutic response assessment also provides a consistent framework for evaluating outcomes, comparing interventions, and identifying factors associated with treatment success or failure.

Therapeutic Response Method - Related Videos

Research

JoVE Journal - Cancer Research

Clinically Relevant Transplantable Tumor Models for Studying Metastatic Ovarian Cancer and Therapeutic Response in Mouse

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2026

Here we present a step-by-step protocol for establishing the intraperitoneal and the intrabursal tumor models to study ovarian cancer cancer progression, metasatsis, and therapeutic response. Further, we describe how to use luciferase-based non-invasive in vivo imaging in these models to monitor tumor progression in mouse.

Escape Response Assay: A Method to Study the Response of Zebrafish Larva to Touch Stimuli

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2023

This video describes the touch-evoke response assay, which measures the response of the zebrafish larva to touch stimuli.

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Therapeutic Drug Monitoring: Drug Analysis Methods

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2025

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

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Cited by 2 •

2017

This protocol describes the in vitro comparison of two key functional characteristics of rituximab: target binding and complement-dependent cytotoxicity (CDC) induction. The methods were employed for a side-to-side comparison between reference rituximab and a rituximab biosimilar. These assays can be employed during biosimilar development or as a quality control in their production.

Research

JoVE Journal - Medicine
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A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

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Cited by 14 •

2013

We describe a novel in vivo imaging technique that couples fluorescent chimeric mice with intracranial windows and high-resolution 2-photon microscopy. This imaging platform aids studies of dynamic changes in brain tissue and microvasculature, at a single-cell level, following pathological insults and is adaptable to assess intracranial drug delivery and distribution.

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