Hybrid Deep Learning

Hybrid deep learning is an approach that combines neural networks with other computational methods, model architectures, or domain-specific knowledge to address complex prediction and decision-making problems. It can integrate complementary components, such as convolutional and recurrent layers, physics-based models, optimization algorithms, or traditional machine-learning techniques, allowing one method to extract patterns while another represents temporal behavior, constraints, or established system relationships. In engineering, hybrid deep learning supports tasks including structural monitoring, process control, fault diagnosis, system modeling, and design optimization. By combining data-driven learning with mechanistic or analytical information, it can improve interpretability, efficiency, robustness, and performance when data are limited or physical constraints are important.

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Research

JoVE Journal - Bioengineering

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

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Cited by 6 •

2023

Worldwide medical blood parasites were automatically screened using simple steps on a low-code AI platform. The prospective diagnosis of blood films was improved by using an object detection and classification method in a hybrid deep learning model. The collaboration of active monitoring and well-trained models helps to identify hotspots of trypanosome transmission.

Research

JoVE Journal - Biology
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Deep Learning-Based Segmentation of Cryo-Electron Tomograms

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Cited by 53 •

2022

This is a method for training a multi-slice U-Net for multi-class segmentation of cryo-electron tomograms using a portion of one tomogram as a training input. We describe how to infer this network to other tomograms and how to extract segmentations for further analyses, such as subtomogram averaging and filament tracing.

Education

JoVE Core - Chemistry

Hybridization of Atomic Orbitals I

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2020

The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...

Hybridization of Atomic Orbitals II

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2020

sp3d and sp3d 2 Hybridization To describe the five bonding orbitals in a trigonal bipyramidal arrangement, we must use five of the valence shell atomic orbitals (the s orbital, the three p orbitals, and one of the d orbitals), which gives five sp3d hybrid orbitals. With an octahedral arrangement of six hybrid orbitals, we must use six valence shell atomic orbitals (the s orbital, the three p orbitals, and two of the d orbitals in its valence shell), which gives six sp3d 2 hybrid orbitals.

Whole-Mount In Situ Hybridization

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2023

Whole-mount in situ hybridization (WMISH) is a common technique used for visualizing the location of expressed RNAs in embryos. In this process, synthetically produced RNA probes are first complementarily bound, or "hybridized," to the transcripts of target genes. Immunohistochemistry or fluorescence is then used to detect these RNA hybrids, revealing spatial and temporal patterns of gene expression. Unlike traditional in situ hybridization techniques, which require thin tissue sections whose...

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