Dermal Neurons
Dermal Neurons - Related Videos
03:32
Generating Neurons by Reprogramming Human Dermal Fibroblast Cells
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2025
The video demonstrates the generation of neurons from adult human dermal fibroblasts (aHDFs). The aHDFs are reprogrammed using a lentiviral vector carrying genes for neuronal transcription factors and short hairpin RNAs (shRNAs). The shRNAs inhibit the expression of a neuronal transcriptional repressor, and the neuronal transcription factors activate genes to differentiate aHDFs into neurons. These reprogrammed aHDFs are cultured in an early and a late neuronal conversion medium to generate...
06:04
Murine Dermal Fibroblast Isolation by FACS
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Cited by 28 •
2016
Fibroblast behavior underlies a spectrum of clinical entities, but they remain poorly characterized, largely due to their inherent heterogeneity. Traditional fibroblast research relies upon in vitro manipulation, masking in vivo fibroblast behavior. We describe a FACS-based protocol for the isolation of mouse skin fibroblasts that does not require cell culture.
05:52
Murine Dermal Lymphatic Endothelial Cell Isolation
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Cited by 1 •
2023
This paper describes a method for magnetic bead-based isolation of murine endothelial cells from dermal lymphatic capillaries. The isolated lymphatic endothelial cells can be used for downstream in vitro experiments and protein expression analysis.
04:27
Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears
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2025
This article details an open anterior capsular reconstruction technique using human dermal allograft for irreparable subscapularis tears, providing structural support and enhancing functional outcomes through precise graft fixation and rehabilitation.
12:47
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
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Cited by 8 •
2014
Here we describe an adaptation of protocols used to induce homeostatic plasticity in neurons for the study of plasticity of astrocytic G protein-coupled receptors. Recently used to examine changes in astrocytic group I mGluRs in juvenile mice, the method can be applied to measure scaling of various astrocytic GPCRs, in tissue from adult mice in situ and in vivo, and to gain a better appreciation of the sensitivity of astrocytic receptors to changes in neuronal activity.
FAQs
Neuropeptide release provides a chemical route through which activated dermal neurons affect nearby immune cells, blood vessels, and epithelial barriers. This signaling complements the electrical impulses that carry sensory information, allowing neural activity to influence local physiology. In infection and inflammation research, the connection helps explain how sensory activation may accompany coordinated changes in tissue defense and repair.
These stimulus classes represent distinct environmental or tissue conditions that can activate dermal neurons. Signals associated with tissue damage or infection are especially relevant because they connect sensory detection with local inflammatory and defensive responses. Examining how activation follows different inputs can help relate the initiating condition to outcomes such as pain, barrier changes, or altered tissue physiology.
Neuroimmune communication links neural activity with immune, vascular, and epithelial functions instead of treating these systems as independent. That coordination may help organize pain, inflammation, antimicrobial defense, and tissue repair at the same site. Its importance in immunology and infection research lies in explaining how host responses are integrated during tissue stress or pathogen-associated conditions.
Research on dermal neurons can connect sensory activation with local changes in inflammation, antimicrobial defense, pain, tissue repair, and epithelial barrier function. These relationships provide a framework for examining how host responses develop in affected skin. The resulting information may clarify whether neural signaling contributes to protective coordination, undesirable inflammation, infection-related pain, or impaired barrier function.
They provide a cutaneous perspective on host defense by linking signals from damaged or infected tissue with nearby immune and epithelial responses. This relationship can help investigators consider pain and inflammation alongside antimicrobial defense and repair. Studying that interface may improve understanding of how the skin coordinates responses to pathogens rather than viewing infection solely as an immune-cell process.
Dermal neuron research may identify targets for conditions in which neural signaling and local tissue responses become clinically important. The overview highlights inflammatory skin disease, infection-related pain, and impaired barrier function as relevant areas. Investigators can therefore ask whether modifying neuroimmune communication could influence symptoms or tissue outcomes while preserving the coordinated responses needed for defense and repair.