Lung Pathology
Lung Pathology - Related Videos
05:15
Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung
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Cited by 22 •
2013
The use of a model that mimics the condition of lung diseases in humans is critical for studying the pathophysiology and/or etiology of a particular disease and for developing therapeutic intervention. Here a noninvasive intratracheal intubation method that can directly deliver exogenous materials to mouse lungs is presented.
08:54
Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
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Cited by 19 •
2020
Intravenous injection of cancer cells is often used in metastasis research, but the metastatic tumor burden can be difficult to analyze. Herein, we demonstrate a tail-vein injection model of metastasis and include a novel approach to analyze the resulting metastatic lung tumor burden.
05:35
Lung Instillation and Fixation: Introducing Liquid into the Trachea and Fixing Lungs to Measure the Fixed Lung Volume
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2023
This video describes a simple and reliable method of introducing liquid into the trachea for lung instillation, fixation, and lung volume measurement.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
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Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
FAQs
Once pathogens breach airway defenses, innate immune cells detect the disturbance and release cytokines, signaling proteins that coordinate inflammation. These signals recruit leukocytes to pulmonary tissue, where the response can affect alveolar epithelial cells and capillary endothelial cells. The resulting cellular injury helps explain why infection may progress from local inflammation to edema and impaired gas exchange.
The balance between the infectious agent and the host response strongly influences the resulting lesion. In some settings, inflammation produces edema and disrupts gas exchange; in others, it promotes granulomatous inflammation, tissue destruction, or fibrosis. Lung pathology therefore evaluates disease as an interaction between pathogen-related injury and the intensity or character of immune activation.
The distinction is approached by integrating structural, molecular, imaging, and clinical evidence rather than relying on a single observation. Histology can reveal patterns of tissue injury and inflammation, while molecular assays, imaging, and clinical specimens add complementary information. Combining these sources helps clarify whether pulmonary abnormalities reflect an infectious process, an immune response, or both.
These approaches provide complementary views of pulmonary disease. Histology examines structural abnormalities in tissue, molecular assays contribute molecular evidence, imaging shows changes within the lungs, and clinical specimens connect findings to the affected individual. Used together, they help researchers and clinicians distinguish disease patterns, clarify progression, and relate tissue changes to immunological or infectious mechanisms.
Edema, impaired gas exchange, granulomatous inflammation, tissue destruction, and fibrosis represent important outcomes to assess. Their presence indicates that inflammation or infection has affected different structural and functional features of the lung. Tracking these changes helps connect cellular and tissue responses with worsening pulmonary function and provides a framework for comparing disease progression across conditions.
In this field, lung pathology supports diagnosis and helps explain how pathogens and host responses shape pulmonary injury. It also contributes to treatment research by identifying disease mechanisms that may be targeted therapeutically. In addition, pathological and immunological findings inform studies of vaccines and host-directed therapies, which aim to improve protection or modify damaging immune responses.