Anterior Chamber Inflammation

Anterior chamber inflammation is an immune-mediated response in the front compartment of the eye, involving the aqueous humor, iris, and ciliary body, and is an important clinical sign in ophthalmic medicine. Breakdown of the blood–aqueous barrier allows inflammatory cells and proteins to enter the aqueous humor, producing cells, flare, pain, redness, photophobia, and sometimes reduced vision. Clinicians assess these findings with slit-lamp biomicroscopy to identify anterior uveitis, infection, trauma, or systemic inflammatory disease. Prompt recognition and treatment can limit complications such as posterior synechiae, elevated intraocular pressure, cataract formation, and permanent visual impairment.

Anterior Chamber Inflammation - Related Videos

Research

JoVE Journal - Medicine

Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis

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2025

Herein, we describe a surgical method to transect the anterior cruciate ligament (ACL) as a reliable model to induce knee osteoarthritis in rodents and methodologies for harvesting knee synovial fluid, measuring knee edema, and assessing osteoarthritis severity.

Research

JoVE Journal - Biology
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In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye

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2024

Here, we describe a platform that allows noninvasive in vivo imaging of liver spheroids engrafted in the anterior chamber of the mouse eye. The workflow spans from generating spheroids from primary liver cells to transplantation into the mouse eye and in vivo imaging at cellular resolution by confocal microscopy.

Grafting Pancreatic Islets: A Method to Implant Pancreatic Islets into the Anterior Chamber of the Mouse Eye for In Vivo Imaging

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2023

This video describes the protocol for grafting human pancreatic islets into the anterior chamber of the mouse’s eye to monitor revascularization of human islet grafts in vivo. It also helps to understand the contribution of recipient versus donor cells in promoting the encapsulation and vascularization of the graft.

Education

JoVE Core - Biology

Inflammation

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2019

Overview In response to tissue injury and infection, mast cells initiate inflammation. Mast cells release chemicals that increase the permeability of adjacent blood capillaries and attract additional immune cells to the wound or site of infection. Neutrophils are phagocytic leukocytes that exit the bloodstream and engulf invading microbes. Blood clotting platelets seal the wound and fibers create a scaffold for wound healing. Macrophages engulf aging neutrophils to end the acute inflammatory...

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

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Cited by 2 •

2018

The goal of the protocol is to show longitudinal intravital real-time tracking of thymocytes by laser scanning microscopy in thymic implants in the anterior chamber of the mouse eye. The transparency of the cornea and vascularization of the graft allows for continuously recording progenitor cell recruitment and mature T-cell egress.

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