Deep Spinal Stimulation

Deep spinal stimulation is a neuromodulation technique that delivers targeted electrical impulses to deeper regions of the spinal cord to alter abnormal neural signaling, making it important in medicine and neuroscience. An implanted pulse generator sends controlled currents through electrodes positioned near the spinal cord, where stimulation can influence sensory and motor pathways and modify how signals are processed. Researchers and clinicians investigate this approach for conditions involving chronic pain, impaired movement, or disrupted spinal circuitry, while ongoing work examines electrode placement, stimulation parameters, safety, and long-term therapeutic outcomes.

Deep Spinal Stimulation - Related Videos

Research

JoVE Journal - Neuroscience

Deep Brain Stimulation with Simultaneous fMRI in Rodents

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Cited by 21 •

2014

This protocol describes a standard method for simultaneous functional magnetic resonance imaging and deep brain stimulation in the rodent. The combined use of these experimental tools allows for the exploration of global downstream activity in response to electrical stimulation at virtually any brain target.

Trans-Spinal Direct Current Stimulation of a Rat's Spinal Motoneuron

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2025

This video describes the in vivo intracellular recording of rat motoneurons under trans-spinal direct current stimulation. The protocol describes how to measure membrane properties and record the rhythmic firing of motoneurons before, during, and after anodal or cathodal polarization of the spinal cord.

Research

JoVE Journal - Behavior
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How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

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Cited by 13 •

2017

The H1 deep transcranial magnetic stimulation coil is FDA-cleared for the treatment of depression. We demonstrate how to utilize the H1 for other conditions, such as auditory hallucinations and PTSD, by moving the helmet to different locations over the subject's skull.

Research

JoVE Journal - Medicine
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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

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Cited by 27 •

2014

Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.

Deep Brain Stimulation as a Treatment for Drug Addiction in a Rat Model

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2025

Source: Batra, V., et al. A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration. J. Vis. Exp. (2016).This video demonstrates a rat model of drug addiction in which the animal self-administers intravenous methamphetamine by pressing a lever, leading to compulsive drug-seeking behavior driven by dopamine release in the nucleus accumbens. To counteract this, the rat undergoes deep brain stimulation (DBS) via an implanted bipolar...

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