Lumbar Degenerative Disease

Lumbar degenerative disease is a group of age-related disorders affecting the intervertebral discs, facet joints, and other structures of the lower spine, and it is a common cause of back pain and impaired mobility. With progressive disc dehydration and loss of height, abnormal mechanical loading can stress facet joints, narrow neural spaces, and contribute to inflammation or nerve compression. Clinicians evaluate symptoms alongside physical examination and imaging to distinguish degeneration from other causes of pain. Treatment may include exercise-based rehabilitation, pain management, and, when persistent nerve compression or instability causes substantial disability, surgical intervention. Research continues to improve early diagnosis and individualized care.

Lumbar Degenerative Disease - Related Videos

Research

JoVE Journal - Medicine

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

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2025

This protocol presents the operative technique of multilevel Oblique Lumbar Interbody Fusion (OLIF) in a step-by-step manner, elaborating on the critical steps for achieving optimal outcomes.

Education

JoVE Core - Pathophysiology

Degenerative Disc Disease I: Introduction

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2026

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Degenerative Disc Disease ll: Pathophysiology

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2026

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

Research

JoVE Journal - Medicine
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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

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Cited by 8 •

2021

The non-human primate (NHP) is an ideal model for studying human retinal cellular therapeutics due to the anatomical and genetic similarities. This manuscript describes a method for submacular transplantation of retinal pigment epithelial cells in the NHP eye and strategies to prevent intraoperative complications associated with macular manipulation.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

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Cited by 12 •

2021

This protocol presents a novel experimental model of proinflammatory, degenerative bovine organ culture to simulate early-stage intervertebral disc degeneration.

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