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1Department of Ophthalmology, Yong Loo Lin School of Medicine,National University of Singapore, 2Department of Ophthalmology,National University Hospital, Singapore, 3Institute of Molecular and Cell Biology (IMCB),Agency for Science, Technology and Research (A*STAR), 4Singapore Eye Research Institute (SERI), 5UCL Institute of Ophthalmology, 6Academic Clinical Program in Ophthalmology,Duke-NUS Medical School, 7Macula Center Saar, Eye Clinic Sulzbach,Knappschaft Hospital Saar, 8Department of Ophthalmology,University of Bonn
Chapters
- 00:04Introduction
- 01:22Vitrectomy
- 04:13Microscope-Integrated Optical Coherence Tomography (miOCT)-Guided Foveal Detachment
- 05:49Removal of Native Retinal Pigment Epithelium
- 06:21miOCT-Guided Graft Implantation, Position Adjustment, and Subretinal Fluid Drainage
- 08:33Results: Assessment of the Retinal Pigment Epithelial Graft
- 10:33Conclusion
The non-human primate (NHP) is an ideal model for studying human retinal cellular therapeutics due to the anatomical and genetic similarities. This manuscript describes a method for submacular transplantation of retinal pigment epithelial cells in the NHP eye and strategies to prevent intraoperative complications associated with macular manipulation.
