Rabbit Ear Ischemia
Rabbit Ear Ischemia - Related Videos
03:17
An Experimental Model of Peripheral Ischemia: A Procedure to Generate Peripheral Ischemia via Femoral Artery Ligation in a Rabbit
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2025
In this video, we demonstrate a surgical procedure to induce peripheral ischemia via femoral artery ligation in a rabbit. This method provides an effective experimental model for peripheral vascular disease research.
06:29
Inducing Ischemia-reperfusion Injury in the Mouse Ear Skin for Intravital Multiphoton Imaging of Immune Responses
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Cited by 15 •
2016
This protocol describes the induction of an ischemia-reperfusion (IR) model on mouse ear skin using magnet clamping. Using a custom-built intravital imaging model, we study in vivo inflammatory responses post-reperfusion. The rationale behind the development of this technique is to extend the understanding of how leukocytes respond to skin IR injury.
06:11
Model of Ischemia and Reperfusion Injury in Rabbits
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Cited by 1 •
2023
The present study demonstrates a highly reproducible animal model of acute regional myocardial ischemia and reperfusion injury in rabbits using a left mini-thoracotomy for survival cases or a midline sternotomy for non-survival cases.
01:30
Blood Collection in Rabbits
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Blood sampling is commonly performed in laboratory rabbits for research and clinical applications. The collection site is selected based on the required sample volume, sampling frequency, and study objectives. As a general...
01:27
Compound Administration in Rabbits II
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Compounds can be administered to rabbits by subcutaneous, intramuscular, or intravenous injection depending on the study objectives, required absorption profile, and characteristics of the test article. Prior to administration,...
FAQs
Reduced perfusion limits the delivery of oxygen and nutrients to the affected ear tissue. Cells consequently experience altered metabolism, and prolonged deprivation can lead to tissue injury. The severity and distribution of these changes depend on the extent of vascular compromise and the tissue region involved, making the model useful for examining local microvascular responses.
Reestablishing circulation may trigger ischemia-reperfusion mechanisms rather than producing only recovery. The return of blood flow can add oxidative stress and inflammation to the damage initiated during oxygen and nutrient deprivation. Studying both phases helps investigators distinguish injury caused by the initial interruption from injury associated with vascular restoration.
The model can be used to examine microvascular function, tissue survival, wound healing, and angiogenesis. These processes reflect different stages of vascular compromise and recovery, from early perfusion changes to longer-term repair. Examining them together helps connect circulation status with whether tissue remains viable and how effectively it recovers.
Researchers can assess how the degree of vascular compromise, the affected tissue region, and subsequent restoration of circulation influence outcomes. Relevant outcomes include altered metabolism, tissue injury, inflammatory effects, tissue survival, wound healing, and angiogenesis. This controlled framework allows treatments to be evaluated according to whether they preserve perfusion or improve recovery.
In medicine, this experimental model provides a controlled system for investigating consequences of vascular compromise and for testing interventions intended to preserve tissue. Its applications include studies of microvascular function, tissue survival, wound healing, angiogenesis, and reconstructive procedures. Findings can help evaluate whether an intervention limits damage or supports recovery after impaired circulation.
Studies can show whether tissue maintains viability during vascular compromise, how healing progresses afterward, and whether new vessel growth contributes to recovery. The model also supports assessment of treatments designed to preserve perfusion or reduce tissue damage. These outcomes are relevant to reconstructive procedures because successful tissue recovery depends on adequate circulation and repair.