Sjogren's Disease
Sjogren's Disease - Related Videos
05:26
Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
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Cited by 2 •
2024
Here, we present a protocol for the examination of oral Candida infection in patients with primary Sjögren's syndrome, which can be used for timely treatment and, thereafter, avoiding related complications.
07:25
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
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Cited by 1 •
2023
Salivary gland ultrasonography is a promising tool for the diagnosis and evaluation of disease activity and complications in Sjogren's syndrome (SS). The scanning technique for salivary gland ultrasound examination relevant to SS is described in the article.
10:21
Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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2024
This manuscript describes the operational procedures and precautions to probe the potential common pathogenic mechanisms linking primary Sjogren's syndrome and lung adenocarcinoma through bioinformatics analysis and experimental verification.
10:47
An Overview of Genetics and Disease
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2023
Many human diseases are associated with mutations or variations in genetic sequences. Some of these genetic variants are heritable, passed down from generation to generation, while others arise sporadically during an organism’s life and cause diseases such as cancer. Researchers are trying to identify and characterize these genetic alterations in the hopes of improving diagnosis and therapeutic options for patients.In this video, we will examine the history of genetic disease research, and...
09:23
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Cited by 12 •
2012
The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.
FAQs
Lymphocytes infiltrate glandular tissue and create an inflammatory environment that disrupts secretory cells. Autoantibody production adds another immune component, while inflammatory signaling can extend beyond the glands. Together, these processes reduce normal tear and saliva secretion and help explain why the condition may produce both localized dryness and broader systemic inflammation.
The immune activity is not necessarily limited to the glands. Broader systemic inflammation may contribute to fatigue, joint symptoms, or involvement of other organs. This wider pattern matters clinically because evaluation and follow-up must consider more than glandular dryness, especially when a person reports persistent symptoms outside the eyes and mouth.
Clinicians do not rely on dryness symptoms alone because several conditions can produce similar complaints. Instead, they combine the symptom pattern with ocular and oral tests, blood markers, and sometimes salivary-gland biopsy. This multi-part assessment helps distinguish immune-mediated gland dysfunction from other explanations and provides a more informative basis for ongoing care.
Evaluation may include ocular tests that assess the effects of reduced tear production, oral tests related to saliva and gland function, and blood markers associated with the disease. When the diagnosis remains uncertain or additional tissue evidence is needed, clinicians may sometimes use a salivary-gland biopsy. The combined results support clinical distinction from other causes of dryness.
Management focuses on relieving gland dysfunction while protecting tissues affected by reduced tears and saliva. Ocular care addresses dry-eye effects, and oral care helps protect dental health when salivary production is reduced. These measures are part of longer-term management rather than a single intervention, because gland-related symptoms and tissue risks require continued attention.
Broader monitoring becomes important when fatigue, joint symptoms, systemic inflammation, or possible organ involvement accompanies glandular complaints. Care can then address both symptom relief and signs of disease outside the eyes and mouth. This approach supports long-term follow-up, helps organize medical evaluation, and allows management to reflect the person's overall pattern of involvement.