Thrombus Aspiration
Thrombus Aspiration - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
06:29
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
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Cited by 6 •
2019
The goal of this article is to describe how cardiac magnetic resonance can be used for the evaluation and diagnosis of a suspected cardiac thrombus. The method presented will describe data acquisition as well as the pre-procedure and post-procedure protocol.
FAQs
Negative pressure creates a pressure gradient that draws thrombus material into the aspiration catheter. The clinician may also manipulate the catheter to engage the clot and improve removal of obstructing fragments. Together, these actions can reduce the amount of thrombotic blockage and help re-establish blood flow when vascular obstruction produces acute ischemia.
Catheter manipulation can help the device reach or engage different portions of the thrombus rather than relying on suction alone. This may support extraction of clot fragments and reduce residual obstruction within the vessel. Its role is particularly relevant when the thrombus requires coordinated catheter movement and aspiration to support revascularization.
Imaging and clinical assessment help determine whether thrombus aspiration is appropriate for a particular vascular obstruction. They provide information for patient selection and help clinicians consider the location and consequences of thrombotic blockage. These assessments also support efforts to limit complications, including distal embolization, during clot-management procedures.
Thrombus aspiration may be combined with other endovascular treatment when aspiration alone does not provide the intended revascularization result. The catheter can remove clot fragments while an adjunctive intervention addresses the remaining vascular obstruction. This combined approach places aspiration within a broader treatment strategy rather than treating it as an isolated maneuver.
In medicine, thrombus aspiration can support revascularization in selected coronary, peripheral, or other vascular interventions. Its relevance is greatest when a thrombotic obstruction contributes to acute ischemia and restoration of flow is needed. The specific vascular setting does not eliminate the need for imaging and clinical assessment to guide appropriate use.
The intended outcome is reduced vessel blockage with improved blood flow after thrombotic material is removed. Clinicians must also consider whether clot fragments could migrate distally, producing distal embolization. Imaging, clinical assessment, catheter manipulation, and possible adjunctive treatment help balance the potential revascularization benefit against this procedural concern.