Thrombus Burden
Thrombus Burden - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
06:29
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
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Cited by 6 •
2019
The goal of this article is to describe how cardiac magnetic resonance can be used for the evaluation and diagnosis of a suspected cardiac thrombus. The method presented will describe data acquisition as well as the pre-procedure and post-procedure protocol.
FAQs
A greater thrombus burden can narrow a vessel more extensively, reducing circulation and potentially progressing to complete blockage. The resulting loss of downstream blood flow can threaten tissue oxygenation and produce ischemia. Its clinical effect therefore depends not only on clot presence, but also on the extent of obstruction within the affected vessel or cardiac chamber.
Thrombus burden can increase when platelet activation and the coagulation cascade continue to generate fibrin. Fibrin stabilizes the accumulating mass of blood cells, allowing the clot to become more extensive within the affected vessel or chamber. This mechanism explains why clinical assessment considers the amount of clot, rather than simply recording whether a thrombus exists.
Location determines which circulation is threatened and how an obstruction may affect tissue perfusion. A clot positioned within a critical vessel or cardiac chamber may restrict blood flow, contribute to ischemia, or create a risk of embolization if material moves elsewhere. Consequently, clinicians interpret thrombus burden together with its anatomical position when judging disease severity.
Clinicians estimate thrombus burden through imaging, angiography, or direct examination during an intervention. These approaches can provide information about the clot’s location and extent, although the available view depends on the clinical setting and the structure being evaluated. The resulting assessment supports diagnosis and helps determine how seriously the obstruction may affect circulation.
The estimated amount and extent of clot can help clinicians select or adjust strategies intended to restore circulation or limit further clotting. In the source context, these include reperfusion approaches and anticoagulant strategies. Burden assessment is therefore not only diagnostic; it also connects the observed obstruction with decisions about managing impaired blood flow.
A change in thrombus burden can help evaluate whether treatment is affecting the clot and whether circulation may be improving or worsening. Follow-up assessment may also help identify persistent obstruction and potential complications, including tissue ischemia or embolization. Comparing burden over time therefore provides context for interpreting treatment response rather than relying on symptoms alone.