Barrel Cortex

The barrel cortex is a specialized region of the somatosensory cortex that processes tactile information, particularly signals from the whiskers of rodents. Sensory input from each whisker travels through the trigeminal pathway to the thalamus and then to a corresponding cortical barrel, where neurons organized in column-like circuits encode touch, movement, and object features. Because its whisker-to-barrel map is anatomically distinct and experimentally accessible, the barrel cortex is a leading model for studying sensory coding, cortical development, neural plasticity, and circuit organization. Research in this system also helps clarify how the brain integrates sensory signals to guide perception and behavior.

Barrel Cortex - Related Videos

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JoVE EoE - Neuroimaging

Functional Magnetic Resonance Spectroscopy of the Rat Barrel Cortex During Whisker Stimulation

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2025

Source: Blanc, J., et al. Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation. J. Vis. Exp. (2019)This video demonstrates the method of analyzing metabolic changes in the rat barrel cortex using functional magnetic resonance spectroscopy during whisker stimulation. Baseline metabolite spectra are compared with stimulated spectra to detect lactate increase in the barrel cortex, confirming successful neuronal activation.

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

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Cited by 4 •

2019

After checking by blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) that the corresponding somatosensory barrel field cortex area (called S1BF) is correctly activated, the main goal of this study is to quantify lactate content fluctuations in the activated rat brains by localized proton magnetic resonance spectroscopy (1H-MRS) at 7 T.

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

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Cited by 1 •

2025

The presented protocol describes the use of transmission electron microscopy (TEM) to quantify circadian changes in the mouse barrel cortex, mainly focusing on synapse number and dendritic spine morphology.

Research

JoVE Journal - Neuroscience
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Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

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Cited by 19 •

2015

We demonstrate the fabrication, calibration and properties of two types of ion-selective microelectrodes (double-barreled and concentric) for measurement of ion concentrations in brain tissue. These are then used in the mouse hippocampal slice preparation to show that excitatory activity changes both extracellular potassium and sodium concentrations.

From Constructs to Crystals – Towards Structure Determination of β-barrel Outer Membrane Proteins

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Cited by 8 •

2016

β-barrel outer membrane proteins (OMPs) serve many functions within the outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts. Here, we hope to alleviate a known bottleneck in structural studies by presenting protocols for the production of β-barrel OMPs in sufficient quantities for structure determination by X-ray crystallography or NMR spectroscopy.

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