Brain Electrode Insertion

Brain electrode insertion is a neurosurgical technique for placing electrodes within or on the brain to record neural activity or deliver electrical stimulation. During the procedure, operators guide an electrode toward a defined neural target, where conductive contacts detect voltage changes from nearby neuronal populations or apply controlled currents. In neuroscience, these recordings help characterize brain circuits, neuronal signaling, and disease-related dysfunction, while stimulation supports experimental studies and therapeutic development. Careful targeting and monitoring are essential because placement influences signal quality, stimulation effects, and tissue safety.

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JoVE EoE - Neurophysiology

Implantation of an Electrode Assembly in a Mouse Brain for Electrophysiological Recording

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2025

This video demonstrates a technique for implanting an electrode assembly into a mouse brain. The assembly contains bipolar electrodes to record activity from the hippocampus and a reference electrode to obtain baseline activity from the cerebellum. An anesthetized mouse is placed on a stereotaxic frame, and the electrode assembly is implanted in the target brain region. The animal is then allowed to recover before performing electrophysiological recording.

Monitoring the Brain Cortex with a Multi-Electrode Array in Response to Seizure-Inducing Agents

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2025

In this video, the effects of transcranial direct-current stimulation (tDCS) on brain slices containing the anterior cingulate cortex (ACC) and thalamus regions are investigated, using a multi-electrode array (MEA) to measure electric signals. By delivering electric pulses and infusing seizure-inducing drugs, the study investigates the ACC response to seizures.

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

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Cited by 8 •

2015

A method for implanting electrodes into the subthalamic nucleus (STN) of rats is described. Better localization of the STN was achieved by using a microrecording system. Furthermore, a stimulation set-up is presented that is characterized by long-lasting connections between the head of the animal and the stimulator.

Brain Mapping Using a Graphene Electrode Array

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2023

We present a graphene array-based brain mapping procedure to reduce the invasiveness and improve spatiotemporal resolution. Graphene array-based surface electrodes exhibit long-term biocompatibility, mechanical flexibility, and suitability for brain mapping in a convoluted brain. This protocol allows for constructing multiple forms of sensory maps simultaneously and sequentially.

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

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Cited by 5 •

2016

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

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