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Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
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Chapters
- 00:05Title
- 00:59Preparation of Medial Thalamus-anterior Cingulate Cortex Brain Slice
- 03:01Preparation of Perfusion Chamber for Multielectrode Array Recording and Electric Field Generation
- 04:23Electrically-induced Cortical Synaptic Responses and Seizure-like Activity
- 05:58Testing Effect of DCS on Evoked Cortical Responses
- 07:37Results: Testing of Evoked Responses and Effect of DCS on Seizure Activity
- 08:37Conclusion
Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.
Tags
Direct-current StimulationMulti-electrode Array RecordingSeizure-like ActivityMice Brain Slice PreparationExperimental ProcedureRecording ChamberDirect Current Stimulation EffectMulti-electrode ArrayMouse Brain SliceSpecific Pathway EvaluationSurgical Instruments SterilizationSkull Exposure And TrimmingOlfactory Bulbs RemovalBrain Transfer To BeakerIce Cold ACSFMT-ACC PathwaySagittal CutSubcortical Anatomy Display
