Brain Network Activity

Brain network activity is the coordinated electrical and chemical signaling among interconnected neurons and brain regions that supports perception, cognition, emotion, and behavior. It arises as neuronal signals propagate through synapses and circuits, producing patterns of synchronization, oscillation, and functional connectivity that can change with sensory input, learning, or brain state. Neuroscientists study these patterns using methods such as electrophysiology, electroencephalography, and functional neuroimaging to link network dynamics with specific functions. This research helps explain how distributed brain systems operate, identify disruptions associated with neurological and psychiatric disorders, and guide the development of diagnostic tools and targeted interventions.

Brain Network Activity - Related Videos

Research

JoVE Journal - Neuroscience

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

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Cited by 3 •

2020

This protocol describes the preparation of horizontal hippocampal-entorhinal cortex (HEC) slices from mice exhibiting spontaneous sharp-wave ripple activity. Slices are incubated in a simplified interface holding chamber and recordings are performed under submerged conditions with fast-flowing artificial cerebrospinal fluid to promote tissue oxygenation and the spontaneous emergence of network-level activity.

Measuring the Electrophysiological Activity of Neuronal Networks Using Micro-Electrode Arrays

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2025

The video demonstrates how to use a microelectrode array (MEA) to record the electrophysiological activity of neurons derived from human induced pluripotent stem cells (hiPSCs). Electrophysiological activity from a multiwell MEA containing a neuron-astrocyte co-culture is recorded to detect action potentials from multiple neurons in the network, confirming the successful differentiation of hiPSCs into neurons.

Recording Electrophysiological Activity of the Neuronal Network in a Neuron-Astrocyte Co-culture

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2025

This video demonstrates establishing a neuron-astrocyte co-culture for recording neuronal network activity. Upon establishing the co-culture of motor neurons and astrocytes on a multi-electrode array (MEA) plate, the synchronous rhythmic electrical activity of the neuronal network was recorded extracellularly using the MEA.

Research

JoVE Journal - Neuroscience
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Investigating The Network-Wide Mechanisms of Pallidal Deep Brain Stimulation Using High-Density Microelectrode Arrays

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2026

Here, we describe a protocol for ex vivo high-density microelectrode array recordings from acute cerebellar brain slices of a dystonic hamster model that received in vivo. continuous pallidal deep brain stimulation for 11 days.

Soft Pneumatic Robot Modulates Graph Theory Metrics of Brain Network for Hand Rehabilitation After Stroke

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2025

This study explores the effects of a configurable soft pneumatic robot on enhancing whole-brain network topology post-stroke. Graph theory analysis indicates significant improvements in clustering coefficient, path length, and global efficiency. Findings highlight the potential of programmable robotic protocols to modulate neuroplasticity and optimize functional recovery in stroke rehabilitation.

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