Brain Tumor
Brain Tumor - Related Videos
03:45
Tumor Treating Fields Application in Human Brain Tumor Models: A Non-invasive Technique to Deliver Alternating Electric Fields to Human Brain for Treating Brain Tumor
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2023
This video demonstrates the application of Tumor Treating Fields or TTFields in human brain tumor models. This non-invasive technique delivers low-intensity alternating electric fields directly to the brain, resulting in inhibition of cell division and subsequent apoptosis.
10:13
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
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Cited by 29 •
2015
Many types of human brain tumors are localized to specific regions within the brain and are difficult to grow in culture. This protocol addresses the role of tumor microenvironment and investigates new drug treatments by analyzing fluorescent primary brain tumor cells growing in an organotypic mouse brain slice.
02:46
Establishing a Brain Tumor in an Organotypic Slice Co-culture Model
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2025
This video demonstrates the development of a 3D co-culture system. Mouse brain slices are placed on a membrane, and fluorescently labeled human brain tumor cells are allowed to grow on it. Once the system is ready, it is stained for imaging.
08:02
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
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Cited by 9 •
2012
The purpose of this article is to describe the use of an orthotopic glioblastoma model for chemoradiation studies. This article will go though cell processing, implanting, and radiotherapy of the mouse using an intracranial model.
07:02
Blood-Brain Tumor Barrier or BBTB Model: An Adaption of the Blood-Brain Barrier or BBB Model to Evaluate Delivery of Therapeutics to the Tumor
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2023
In this video, we describe a comprehensive protocol to establish an in vitro model mimicking the blood-brain tumor barrier. The model holds promise to understand the delivery of therapeutic agents for the treatment of brain tumors.
FAQs
Tumor growth reflects dysregulation of genetic and cellular controls that normally regulate cell proliferation and survival. The resulting behavior can remain relatively contained or become more invasive, depending on the tumor’s biological characteristics. This distinction helps explain why classification must consider more than the presence of an abnormal mass when guiding treatment decisions.
A tumor can disrupt neural function through its anatomical position, its physical size, or both. Growth near particular brain structures may interfere with their normal operation, while expansion can compress surrounding tissue or increase intracranial pressure. These effects make the relationship between tumor anatomy and neurological consequences important in neuroscience research.
Studying how surrounding neural tissue responds to a tumor provides insight into circuit disruption and the nervous system’s reaction to injury. The tumor therefore serves not only as a clinical problem but also as a model for examining altered neural function. This perspective connects tumor research with broader questions in neuroscience.
Classification draws on several complementary sources of information: neurological examination, magnetic resonance imaging, biopsy, and molecular profiling. Together, these approaches characterize the abnormal growth from clinical, structural, tissue, and molecular perspectives. Their combined findings can support treatment planning rather than relying on a single observation or test.
Magnetic resonance imaging provides structural information about the brain tumor and its relationship to nearby nervous system tissues. Within the broader evaluation, imaging is considered alongside neurological examination, biopsy, and molecular profiling. This multimodal process helps researchers and clinicians classify the tumor and connect its observed features with treatment decisions.
Molecular profiling adds information about the tumor’s biological characteristics to findings from examination, imaging, and biopsy. That information supports classification and can help guide more individualized care. In the broader research context, these data contribute to development of targeted therapies, immunotherapy, and personalized treatment approaches for people with brain tumors.