Microporous Hydrogel
Microporous Hydrogel - Related Videos
02:59
Stereotactic Injection of Hydrogel into a Post-Stroke Mouse Model
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2025
Source: Wilson, K.L., et al. Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke. J. Vis. Exp. (2020)This video demonstrates the stereotaxic injection of a hydrogel into the stroke core of a post-stroke mouse, highlighting its role in scaffold formation that mimics the extracellular matrix, promotes cellular infiltration, and supports angiogenesis, underscoring its neurotherapeutic potential in stroke recovery.
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
08:33
Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
09:09
Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes
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Cited by 3 •
2015
In this paper we describe the interfacial synthesis of conjugated microporous polymers (CMP) on sacrificial substrates, and the dissolution of the substrate for the preparation of freestanding CMP nanomembranes. In addition, we will describe how the fragile nanomembranes can be transferred to other substrates.
09:47
FRET Imaging in Three-dimensional Hydrogels
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Cited by 3 •
2016
Förster resonance energy transfer (FRET) imaging is a powerful tool for real-time cell biology studies. Here a method for FRET imaging cells in physiologic three-dimensional (3D) hydrogel microenvironments using conventional epifluorescence microscopy is presented. An analysis for ratiometric FRET probes that yields linear ratios over the activation range is described.
FAQs
Pore architecture influences how readily molecules, cells, and fluids move through the matrix. Larger or better-connected pathways can favor transport and cellular movement, whereas tighter connectivity can constrain them. In neural models, this control matters because diffusion and cell access affect whether cells receive nutrients and whether neurites can extend through the construct.
Polymer composition and cross-linking are central control points. They help determine the network’s mechanical behavior, pore structure, swelling, degradation, and movement of molecules through the hydrated matrix. Adjusting these variables allows researchers to design environments with different combinations of softness, stability, and transport capacity for specific neural culture or tissue-engineering objectives.
Swelling changes the hydrated matrix and can therefore influence pore dimensions, fluid movement, and molecular transport. Degradation changes the network over time, potentially altering its mechanical and organizational support. Considering both properties helps researchers match the material’s changing environment to studies of neural cells, neurite growth, drug delivery, or tissue development.
Its three-dimensional pore network can provide space for cellular organization while allowing nutrient diffusion through the hydrated matrix. The material’s tunable mechanical and transport properties also let researchers adjust the surrounding environment for neural cells. These features make it useful for constructs intended to support neurite growth and investigate how cells respond to physical and biochemical cues.
Researchers can apply these systems in three-dimensional neural cell culture, drug delivery, and models of cellular responses to the surrounding environment. The same matrix can support nutrient movement, cellular organization, or controlled molecular transport, depending on its composition, cross-linking, pore structure, swelling, degradation, and fabrication conditions.
Experiments can evaluate nutrient diffusion, cellular organization, neurite growth, and neural-cell responses to physical or biochemical surroundings. These outcomes connect material properties with biological behavior: changes in pore structure, hydration, mechanics, or degradation may influence how cells organize and how neurites extend through the three-dimensional environment.