Cortical Gyrus Narrowing
Cortical Gyrus Narrowing - Related Videos
07:42
Dissection of Hippocampal Dentate Gyrus from Adult Mouse
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Cited by 208 •
2009
A dissection technique for removal of the dentate gyrus from adult mouse under a stereomicroscope was demonstrated in this video-recorded protocol.
11:13
Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
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Cited by 1 •
2013
Transgenic and knockout mouse models of neurological diseases are useful for studying the role of genes in normal and abnormal neurophysiology. This article describes methodologies which can be used to study long-term potentiation, a cellular mechanism which may underlie learning and memory, in transgenic and knockout freely behaving mouse models of neuropathology.
01:22
Detection of Internal Carotid Artery Narrowing Using Digital Subtraction Angiography
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2025
Position a human patient with internal carotid stenosis, a condition characterized by narrowing of the internal carotid artery, on the imaging table for digital subtraction angiography (DSA). Insert an angiocatheter into the common carotid artery at the fourth cervical vertebra level. Capture a pre-contrast X-ray image to record background structures like bones and soft tissues using X-ray irradiation. Administer an iodine-based contrast medium into the carotid artery. The contrast medium...
03:04
High-Frequency Stimulation to Enhance Neuronal Activation and Neurogenesis in the Mouse Dentate Gyrus
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2025
Source: Zhao, Z. et al. An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation. J. Vis. Exp. (2018)This video demonstrates the protocol for delivering high-frequency deep brain stimulation to a mouse hippocampal dentate gyrus, detailing its effects on neuronal activation, synaptic plasticity, and neurogenesis.
10:55
Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
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Cited by 6 •
2015
We describe two methods for visualization and quantification of dendritic arborization in the hippocampus of mouse models: real-time and extended depth of field imaging. While the former method allows sophisticated topographical tracing and quantification of the extent of branching, the latter allows speedy visualization of the dendritic tree.
FAQs
Several processes may contribute to the appearance of narrower or less prominent gyri. During development, altered coordination of cortical growth or neuronal organization can change gyral form. In other settings, cortical atrophy or another structural change may reduce tissue volume and modify surrounding folds. These possibilities mean that narrowing should be interpreted alongside other anatomical measurements rather than treated as a single diagnostic finding.
Gyral appearance alone does not fully describe cortical structure. Comparing the shape of a gyrus with cortical thickness and the configuration of neighboring sulci provides a broader anatomical context for deciding whether a regional difference reflects developmental variation, reduced tissue volume, or another structural change. This combined assessment improves interpretation of regional cortical architecture in neuroscience research.
Regional patterns can help researchers examine whether particular cortical areas show greater structural vulnerability than others. By relating these anatomical differences to brain development, neurological disease, cognition, behavior, or clinical outcomes, investigators can study connections between cortical architecture and function. The value lies in identifying meaningful spatial patterns, not in interpreting an isolated gyrus without surrounding neuroanatomical context.
Researchers use magnetic resonance imaging to examine gyral shape and prominence across selected cortical regions. They compare the target gyrus with neighboring sulci and evaluate cortical thickness as part of the same structural assessment. These measurements allow investigators to characterize regional anatomy and determine how observed differences fit broader patterns of cortical development, atrophy, or structural alteration.
Assessment focuses on several related features: the shape and prominence of the gyrus, the width or configuration of nearby sulci, and the thickness of the cortex. Considering these features together helps describe whether a regional difference reflects altered folding, tissue-volume change, or another pattern of cortical organization. Related neuroanatomical methods may complement magnetic resonance imaging in this comparison.
These measurements are useful when studies need to characterize cortical structure across development, neurological disease, or regional patterns of vulnerability. Investigators can compare anatomical findings with cognition, behavior, and clinical outcomes to explore how differences in cortical architecture relate to function. The approach supports structural neuroanatomy research rather than serving as a standalone explanation for an individual outcome.
It can provide a structural marker for examining how cortical architecture changes across developmental or disease-related contexts. Researchers may use regional measurements to identify differences in gyral form, cortical thickness, and neighboring sulci, then relate those patterns to tissue volume and organization. Such comparisons help clarify whether cortical structure varies systematically with developmental processes, neurological disease, or clinical features.