Drug Infusion Tracking

Drug infusion tracking is the systematic recording of when, how much, and at what rate a drug enters an experimental subject, supporting accurate interpretation of neuroscience studies. It typically links infusion-pump settings or administration events with synchronized timestamps, enabling researchers to align drug exposure with neural recordings, behavioral measurements, and physiological responses. By documenting dose delivery and experimental timing, this approach helps distinguish drug effects from handling or procedural effects, improves reproducibility, and supports analysis of dose-response relationships. Reliable tracking is especially important in studies of neural circuits, pharmacological modulation, and therapeutic interventions where small timing or dosage differences can influence observed outcomes.

Drug Infusion Tracking - Related Videos

Research

JoVE EoE - Neurotherapeutics

Microfluidic-Based Microinjectrode System for Combined Drug Infusion and Electrophysiology

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2025

Source: Vanegas, M. I., et al. Microinjectrode System for Combined Drug Infusion and Electrophysiology. J. Vis. Exp. (2019)This video demonstrates a microelectrode-based microfluidic device that delivers drug solution through a capillary tube, using an oil-based marker solution for precise volume tracking and enabling simultaneous neural recording and drug infusion.

Continuous Drug Infusion System in Mouse Model: A Surgical Procedure to Implant Micro-osmotic Pump Infusion System in the Mouse Brain for Continuous Drug Delivery

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2025

In this video, we demonstrate the assembly of a micro-osmotic pump brain infusion system followed by its surgical implantation in the mouse skull. This system enables continuous delivery of potential drugs and facilitates the study of their effects on the brain and brain tissue.

Research

JoVE Journal - Neuroscience
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Microinjectrode System for Combined Drug Infusion and Electrophysiology

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Cited by 15 •

2019

We present a microinjectrode system designed for electrophysiology and assisted delivery of experimental probes (i.e., nanosensors, microelectrodes), with optional drug infusion. Widely available microfluidic components are coupled to a cannula containing the probe. A step-by-step protocol for microinjectrode construction is included, with results during muscimol infusion in macaque cortex.

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

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Cited by 1 •

2021

Pancreatic duct infusion is an important technique that can allow for lineage tracing, gene introduction, and cell line-specific targeting. A pancreatic duct infusion technique for drug and viral delivery to pancreatic cells is presented here.

Evaluating the Effect of Continuous Drug Infusion into the Mouse Brain on Peripheral Glucose Levels

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2025

This video demonstrates the effect of continuous drug infusion into the mouse brain on blood glucose levels. Glucose metabolism is assessed by collecting blood from a fasted mouse's tail and measuring glucose levels before and after oral glucose administration. Insulin tolerance is evaluated by injecting insulin in the mouse, with glucose levels recorded at specific intervals.

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