Electrophysiological Examination
Electrophysiological Examination - Related Videos
10:46
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
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Cited by 4 •
2015
Radiation exposure is an underestimated risk in complex ablation procedures. Here, we describe a protocol to significantly decrease fluoroscopy time and dosage for both the patient and the lab staff by using a novel non-fluoroscopic catheter visualization system.
12:09
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Cited by 13 •
2013
To complement commonly used methods to study TRPV4’s, two methods are described: Its mechanosensitivity can be studied by Ca2+-aequorin luminometry in transgenic yeast upon hypo-osmotic challenge. It can also be examined in TRPV4-RNA injected Xenopus oocytes by whole-cell two-electrode voltage clamp or patch clamp in on-cell or excised mode.
05:41
Applying Microfluidics to Electrophysiology
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Cited by 1 •
2007
Microfluidics can be integrated with standard electrophysiology techniques to allow new experimental modalities. Specifically, the motivation for the ...
07:44
Ophthalmoscopic Examination
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA The simplest ophthalmoscopes consist of an aperture to look through, a diopter indicator, and a disc for selecting lenses. The ophthalmoscope is primarily used to examine the fundus, or the inner wall of the posterior eye, which consists of the choroid, retina, fovea, macula, optic disc, and retinal vessels (Figure 1). The spherical eyeball...
08:22
Simultaneous fMRI and Electrophysiology in the Rodent Brain
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Cited by 45 •
2010
We have developed a method for simultaneous functional magnetic resonance imaging and electrophysiological recording in the rodent brain, providing a platform for the investigation of the relationship between neural activity and the blood oxygenation level dependent (BOLD) MRI signal.
FAQs
Ion movement across excitable cell membranes produces voltage changes that electrodes can detect. These changes may appear as spontaneous activity generated by the nervous system or as responses following sensory or electrical stimulation. Examining their timing and patterns allows investigators to evaluate how neurons and related excitable tissues generate and transmit signals.
The recording site determines which part of nervous system function is represented in the data. Scalp recordings can reflect activity associated with the brain, whereas peripheral nerves, muscles, or neural tissue provide information from more localized structures. Selecting among these locations helps align the examination with questions about signaling, dysfunction, circuits, or behavior.
Spontaneous signals show ongoing activity without a deliberately introduced stimulus, revealing patterns of baseline neural function. Evoked signals are measured after sensory or electrical stimulation and indicate how excitable cells respond to a defined input. Considering both types can distinguish general activity from responses linked to a particular stimulus or pathway.
These approaches emphasize different recording targets within electrophysiological examination. Electroencephalography supports assessment of electrical activity recorded from the scalp, nerve conduction studies focus on peripheral nerves, and electromyography concerns electrical activity associated with muscles. Together, they extend examination across distinct parts of the nervous system rather than providing interchangeable measurements.
A typical examination begins by selecting the relevant recording location, such as the scalp, a peripheral nerve, muscle, or neural tissue. Electrodes then detect spontaneous activity or responses to sensory or electrical stimulation. The resulting signals are measured and analyzed to characterize neural signaling, identify abnormalities, or examine relationships between neural activity and behavior.
Researchers use these examinations when they need evidence about nervous system function, dysfunction, or treatment response. The results can help localize a problem, follow disease progression, and evaluate whether treatment changes neural activity. In experimental neuroscience, recordings also provide data for studying brain circuits and their relationship to behavior.