Mouse Brain
Mouse Brain - Related Videos
06:28
Isolating Immune Cells from Mouse Brain and Skull
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Cited by 1 •
2024
To investigate the immune response to brain disorders, one common approach is to analyze changes in immune cells. Here, two simple and effective protocols are provided for isolating immune cells from murine brain tissue and skull bone marrow.
02:14
Delivery of a Traumatic Brain Injury to a Mouse Brain
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2025
This video demonstrates the delivery of Traumatic Brain Injury (TBI) in mice. After exposing the skull, the TBI site is marked. The mouse is then positioned under the TBI device. The impact is delivered by lifting the metal rod and allowing it to drop freely onto the impactor, which is in contact with the skull.
07:32
Purification of Mouse Brain Vessels
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Cited by 90 •
2015
We describe a protocol allowing the purification of the mouse brain's vascular compartment. Isolated brain vessels include endothelial cells linked by tight junctions and surrounded by a continuous basal lamina, pericytes, vascular smooth muscle cells, as well as perivascular astroglial membranes.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
04:44
Processing of a Mouse Brain for Downstream Analysis
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2025
This video demonstrates a detailed step-by-step protocol for preparing frozen mouse brain tissue sections for downstream analyses.
FAQs
Neural communication in the mouse brain depends on two linked signaling modes: electrical signals carry activity within neurons, while neurotransmitters transmit information across synaptic connections. This arrangement allows interconnected regions to combine sensory, motor, and internal-regulation signals rather than operating independently, providing a circuit-level basis for behavior.
Synaptic plasticity provides a framework for examining how neural communication changes with experience. In the mouse brain, researchers can relate these changes to learning, memory, and behavior by combining molecular techniques, imaging, or electrophysiology with controlled experiments. This makes plasticity a central process for connecting cellular activity with adaptable neural function.
The mouse brain offers cellular organization, genetic tools, and a behavioral repertoire that support controlled investigation of neural function. However, mouse and human neurobiology are not identical. Findings therefore help connect cells, circuits, and behavior in a tractable model, while researchers must recognize species differences when relating results to human neurological conditions.
A study can pair imaging with electrophysiology, molecular techniques, or targeted genetic manipulation, depending on whether the goal is to examine activity, cellular properties, molecular features, or specific neural components. Researchers then relate these measurements to circuits and behavior. Using complementary approaches helps connect observations at different levels of neuroscience.
Experiments can examine neural development, synaptic plasticity, memory, learning, behavior, and neurological disease. The model is especially useful when researchers need controlled conditions and want to connect a biological change with its effects on neural circuits or observable behavior. These applications span both basic neuroscience and disease-focused investigation.
Targeted genetic manipulation allows researchers to investigate the contribution of selected cells or neural components rather than treating the brain as a uniform system. When combined with behavioral observation and other neuroscience methods, it can help link particular cells and circuits with functions such as learning, memory, or disease-related changes.