Navigated Brain Stimulation
Navigated Brain Stimulation - Related Videos
10:27
A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation
0 Views •
2026
Here, we describe a standardized protocol for motor mapping using nTMS combined with diffusion tensor imaging (DTI)-based reconstruction of the corticospinal tract (CST). The protocol is reproducible, clinically feasible, and readily integrable into routine clinical workflows, providing a robust and valuable framework for motor pathway assessment, neuroplasticity research, and rehabilitation planning.
02:23
Navigational Behavior of Drosophila Larvae in Response to Optogenetic Stimulation of Olfactory Sensory Neurons
0 Views •
2025
This video demonstrates a study of the navigational behavior of Drosophila larvae in response to optogenetic stimulation of olfactory sensory neurons (ORNs). Transgenic Drosophila larvae expressing light-sensitive ion channels in the ORNs are placed on agarose within a behavior arena. Optogenetic stimulation with light opens the channels, causing a cation influx that triggers the transmission of the signal to the brain, and the navigation behavior is recorded.
11:02
Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
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Cited by 17 •
2010
In this article, we examine the methodology and considerations relevant to the combination of TMS and fMRI to examine the effects of brain stimulation on the default network.
08:23
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Cited by 5 •
2016
Resting-state functional-connectivity MRI has identified abnormalities in patients with a wide range of neuropsychiatric disorders, including epilepsy due to malformations of cortical development. Transcranial Magnetic Stimulation in combination with EEG can demonstrate that patients with epilepsy have cortical hyperexcitability in regions with abnormal connectivity.
05:44
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Cited by 7 •
2016
This paper describes the use of quantitative measurement of eye movements in conjunction with stimulation of focal areas of the deep brain in order to study physiology, pathophysiology, and the mechanisms of deep brain stimulation.
FAQs
In navigated transcranial magnetic stimulation, a coil delivers brief magnetic pulses near the selected cortical region. These pulses induce electrical currents in cortical tissue, providing the immediate physiological input used to examine how stimulation of a particular area relates to motor function, language, cognition, or other behavior.
Individualized anatomical guidance links coil position to the participant’s own brain anatomy rather than relying on an uncertain generic location. Imaging-based neuronavigation tracks this relationship during stimulation, reducing anatomical uncertainty and helping researchers apply more consistent targeting across measurements, participants, and experimental protocols.
Coil tracking provides spatial information about where stimulation is being delivered relative to the brain. This allows researchers to associate observed responses with specific cortical regions and to document targeting more precisely. The added spatial reference is especially important when investigating functional maps or relationships between brain regions and behavior.
Researchers can examine how targeted cortical stimulation relates to functions such as movement, language, and cognition. By linking the stimulated location with participant responses or behavioral changes, the method supports functional mapping and helps investigate how particular brain regions contribute to observable abilities and broader brain connectivity.
A typical setup described for this approach combines a neurostimulation coil, brief magnetic pulses, imaging-based neuronavigation, and an individualized anatomical reference. The neuronavigation system tracks coil position relative to the participant’s brain while stimulation is delivered, allowing the experimental protocol to maintain a documented relationship between the coil and selected cortical targets.
Researchers use this approach when they need targeted, anatomically informed stimulation for functional mapping or investigations of brain connectivity. Its applications include studying motor and language areas, examining neurological disorders, and evaluating potential therapeutic interventions. More reproducible targeting can strengthen comparisons across experimental protocols and improve interpretation of stimulation-related findings.