Merry-go-round

A merry-go-round is a rotating platform that illustrates fundamental principles of circular motion, including angular velocity, centripetal acceleration, torque, and rotational inertia. As it spins about a central axis, the platform’s motor or an applied force produces torque, while friction and structural forces maintain rotation; riders experience an inward centripetal force and an apparent outward effect in the rotating frame. Changing the ride’s speed or the distribution of riders alters its angular momentum and energy requirements. In physics education, merry-go-rounds provide an accessible model for analyzing rotational dynamics, conservation laws, friction, and how an object’s distance from the axis affects its motion.

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Research

JoVE Journal - Biochemistry
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Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline

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Cited by 40 •

2017

The determination of the solution structure of a protein by small angle X-ray scattering (SAXS) requires monodisperse samples. Here, we present two possibilities to ensure minimal delays between sample preparation and data acquisition: online size-exclusion chromatography (SEC) and online ion-exchange chromatography (IEC).

Research

JoVE Journal - Chemistry

Total Internal Reflection Absorption Spectroscopy (TIRAS) for the Detection of Solvated Electrons at a Plasma-liquid Interface

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Cited by 9 •

2018

This article presents a total internal reflection absorption spectroscopy (TIRAS) method for measuring short-lived free radicals at a plasma-liquid interface. In particular, TIRAS is used to identify solvated electrons based on their optical absorbance of red light near 700 nm.

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

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Cited by 7 •

2016

Quorum-quenching enzymes are anti-virulent and anti-bacterial options that can mitigate pathogenesis without risk of incurring resistance, by preventing the expression of virulence factors and genes associated with antibiotic resistance and biofilm formation. In this study, we report a method that demonstrates the efficacy of quorum-quenching enzymes in bacterial biofilm disruption.

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

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Cited by 6 •

2016

The ability of metastatic clones to colonize distant sites depends on their proliferation capacity and/or their ability to survive in the host microenvironment without significant proliferation. Here, we present an animal model that allows quantitative visualization of both types of liver colonization by metastatic clones.

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