Depression Symptoms

Depression symptoms are persistent emotional, cognitive, physical, and behavioral changes that can signal a depressive disorder and interfere with daily functioning. They may include low mood, loss of interest or pleasure, changes in sleep or appetite, fatigue, difficulty concentrating, feelings of worthlessness, and thoughts of death; clinicians assess their duration, severity, pattern, and impact rather than relying on one symptom alone. In psychology, recognizing these symptom clusters supports screening, diagnosis, risk assessment, and treatment planning. Careful evaluation also helps distinguish depression from normal sadness and identify co-occurring conditions that may require additional support.

Depression Symptoms - Related Videos

Research

JoVE EoE - Neurotherapeutics

Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

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2025

Source: Sellers, K. K. et al. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J. Vis. Exp. (2023)This video demonstrates the procedure for system setup and data recording to support patient-specific biomarker detection and neurostimulation delivery for treating major depressive disorder.

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

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Cited by 88 •

2015

The unpredictable chronic mild stress (UCMS) protocol is a validated method for studying behavioral and physiological changes associated with chronic stress and depressive symptoms. Eight weeks of imposition of the UCMS protocol induces behavioral changes and poor health outcomes in rodents of either gender.

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

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2024

Here, we present a protocol that investigates the relationship between cognitive symptoms and sleep quality in patients with major depressive disorder. The THINC-integrated tool and polysomnography were used to evaluate cognitive symptoms and sleep quality.

Induction and Evaluation of Depression in Mice Through Chronic Stress Exposure

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2025

Source: Yan, Z., et al. Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice. J. Vis. Exp. (2019).The video demonstrates the process of establishing a mouse model of chronic stress-induced depression and assessing depressive behaviors. The chronic application of various stressors triggers the release of corticosterone, leading to neuronal over-excitation and eventual neuronal death, which results in depression-like symptoms in the mice.

Education

JoVE Core - Biology

Long-term Depression

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2019

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory. Calcium Ion Concentration Mechanism If over time, all...

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