Neurological Maturation

Neurological maturation is the progressive development and refinement of the nervous system that supports changes in cognition, emotion, behavior, and adaptive functioning. It involves processes such as neuronal growth, synaptic formation and pruning, myelination, and increasing specialization of brain networks, which improve the speed, coordination, and efficiency of neural communication over time. In psychology, studying neurological maturation helps explain age-related changes in learning, executive function, social behavior, and emotional regulation. It also provides a framework for understanding individual developmental differences and identifying how biological development may influence psychological wellbeing and vulnerability to neurological or mental health conditions.

Neurological Maturation - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

Education

JoVE Core - Cell Biology

Maturation of Endosomes

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2023

The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB). Changes in location The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...

Research

JoVE Journal - Developmental Biology
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In Vitro Differentiation of Mature Myofibers for Live Imaging

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Cited by 38 •

2017

Muscle cells are among the most complex eukaryotic cells. We present a protocol for the in vitro differentiation of highly mature myofibers that allows for genetic manipulation and clear imaging during all developmental stages.

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

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Cited by 120 •

2015

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral sclerosis.

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