Cardiac Function Assessment
Cardiac Function Assessment - Related Videos
11:38
Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
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Cited by 36 •
2010
Langendorff-mode isolated heart perfusion, in conjunction with 31P NMR spectroscopy, combines the fields of biochemistry and physiology into one experiment. The protocol allows for the dynamic measurement of high energy phosphate content and turnover in the heart while concurrently monitoring physiologic function. When performed correctly, this is a valuable technique in the assessment of cardiac energetics.
09:05
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
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Cited by 25 •
2016
The goal of this protocol is to noninvasively assess cardiac structural and functional changes in a mouse model of heart disease created by transverse aortic constriction, using B- and M-mode echocardiography and color/pulse wave Doppler imaging.
08:41
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
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Cited by 2 •
2013
Contrast enhanced cardiac magnetic resonance (CMR) imaging allows comprehensive in vivo assessment of the heart in small animal models of cardiovascular disease. Here we detail the procedures to perform CMR imaging, reconstruction and analysis using Small Animal Lock-Locker Inversion Recovery (SALLI) in rats.
08:19
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes
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Cited by 10 •
2020
This protocol aims to describe step-by-step the technique of extraction and assessment of cardiac function using skinned cardiomyocytes. This methodology allows measurement and acutemodulation of myofilament function using small frozen biopsies that can be collected from different cardiac locations, from mice to men.
07:26
Isolation of Functional Cardiac Immune Cells
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Cited by 9 •
2011
This method for isolating functional immune cells from the heart provides an alternative to the conventional methods of collagenase digestion, which causes unwanted immune cell activation, resulting in a decreased responsiveness of these cells. Our method of isolation yields functional cardiac immune cells by avoiding problems associated with enzymatic digestion.
FAQs
Each measurement captures a different aspect of cardiac performance. Electrocardiography characterizes electrical conduction, echocardiography shows chamber motion and blood flow, while blood pressure reflects hemodynamic performance and cardiac biomarkers indicate myocardial injury. Combining these findings helps clinicians distinguish electrical abnormalities from structural, pumping, or injury-related problems rather than relying on a single indicator.
Electrocardiography records the heart’s electrical activity and conduction, making it particularly relevant when an abnormal rhythm or conduction problem is suspected. Echocardiography instead provides information about chamber motion and blood flow. Using both approaches links electrical behavior with mechanical performance, which supports a more complete assessment when symptoms may arise from different aspects of cardiac function.
Blood pressure and cardiac biomarkers address separate clinical questions. Blood pressure provides information about hemodynamic performance, whereas biomarkers can indicate myocardial injury. Their results therefore should not be treated as interchangeable. Considered alongside electrical and imaging findings, they help clarify whether an abnormal assessment relates mainly to circulation, heart muscle injury, or another cardiac problem.
Test results gain clinical meaning when interpreted with symptoms and physical examination findings. This integration can support diagnosis and risk stratification by connecting objective measurements with the patient’s presentation. It also helps clinicians individualize care, because the same type of abnormal result may require different interpretation depending on the broader clinical context.
A cardiac evaluation can combine measurements according to the function being investigated: electrical conduction, chamber motion and blood flow, hemodynamic performance, or myocardial injury. Clinicians then interpret the findings together with symptoms and physical examination. This approach creates a structured assessment without depending on one test to answer every clinical question.
The combined findings can help identify arrhythmias, valve disease, heart failure, and ischemia. Different abnormalities may become apparent through electrical recordings, imaging of motion and flow, pressure measurements, or injury-related biomarkers. Because these conditions affect cardiac function in different ways, complementary assessments help guide recognition and support clinical risk stratification.
Repeated cardiac assessments provide objective information for tracking response to treatment. Changes in electrical findings, chamber motion, blood flow, hemodynamic performance, or myocardial injury markers can be considered alongside symptoms and examination results. This follow-up role helps clinicians evaluate whether care is producing the intended effect and supports individualized management over time.
Cardiac measurements provide objective endpoints for research and clinical trials. Electrical, imaging, hemodynamic, and biomarker findings can document cardiac status and changes during an intervention. When investigators interpret these results with relevant clinical findings, the assessments support evaluation of treatment response and provide measurable evidence for comparing outcomes across participants or study time points.