Intradermal Needle

An intradermal needle is a specialized injection device designed to place small volumes of fluid within the dermis, the skin layer beneath the epidermis. This route matters because it enables controlled delivery close to cutaneous immune cells and sensory structures. During administration, the needle enters at a shallow angle, with the bevel oriented upward; correct placement produces a small raised wheal as fluid spreads through the dermal tissue. Intradermal needles therefore support skin testing, localized drug delivery, and selected vaccination procedures, while technique and needle choice influence accuracy, patient comfort, and reproducibility.

Intradermal Needle - Related Videos

Research

JoVE Journal - Immunology and Infection

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

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Cited by 12 •

2016

We describe here a protocol for isolating myeloid cells from mouse skin and draining lymph node following intradermal injection of Plasmodium sporozoites. Flow cytometry of collected cells provides a reliable assay to characterize the skin and draining lymph node inflammatory response to the parasite.

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JoVE Science Education - Clinical Skills

Intraosseous Needle Placement

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2023

Source: Julianna Jung, MD, FACEP, Associate Professor of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA For unstable patients requiring urgent administration of medications, fluids, or blood products, establishing vascular access quickly is essential. However, there are many factors that can complicate placement of a peripheral intravenous cannula (PIV), and it is extremely common for PIV attempts to fail. PIV placement may be technically challenging in small...

Intradermal Immunization with Live Attenuated Sporozoites in a Mouse Model

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2025

This video demonstrates an assay for immunizing a mouse model with live attenuated sporozoites. The radiation-attenuated Plasmodium sporozoites are injected into the dorsal side of the mouse's ear. After injections at multiple locations on both ears, the mouse is allowed to recover.

Needle Thoracostomy

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2015

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A tension pneumothorax is a life-threatening situation in which excess air is introduced into the pleural space surrounding the lung, either through trauma to the chest cavity or as a spontaneous leak of air from the lung itself. Air trapped within the pleural space causes separation of the lung from the chest wall, disrupting normal breathing mechanisms. Pneumothorax may be small without...

Research

JoVE Journal - Immunology and Infection
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Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

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2025

Here we present a protocol for performing a low-dose intradermal inoculation of Mycobacterium avium in a mouse ear to reflect exposure-like conditions.

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