Menopause Model
Menopause Model - Related Videos
01:28
Menopause
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2024
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Cited by 4 •
2019
Clinically, estrogen deficiency in menopausal women may aggravate the incidence of lipid disruption and atherosclerosis. We established an in vivo estrogen deficiency model by bilateral ovariectomy via a double dorsal-lateral incision in apoE-/- mice. The mouse model is applicable for screening exogenous estrogen treatments of cardiovascular dysfunction after menopause.
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Cited by 66 •
2013
Here, we present a systematic approach for developing physiologically relevant, sensitive and specific in vivo assays for interpreting variation in human pathology. Transient genetic manipulation via microinjection of WT and mutant human mRNA and morpholino (MO) antisense oligonucleotides harness the tractability of the developing zebrafish embryo to rapidly assay pathogenic mutations, especially, but not exclusively, in the context of human developmental disorders.
02:00
Molecular Models
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2020
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules. Skeletal Model Simpler two-dimensional representations of chemical compounds are accomplished using skeletal models. The illustration shows only the molecular framework or bonds without explicitly showing the atoms. In this representation, many of the carbon atoms...
14:26
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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Cited by 16 •
2014
Two exercise paradigms were tested on a newly developed chemically induced menopausal mouse model to examine the impact of menopause on exercise capacity and cardiac adaption to exercise.
FAQs
The way ovarian hormone depletion is produced shapes what a menopause model represents. Ovariectomy removes ovarian tissue, follicle destruction reduces the follicular source of hormones, and age-related reproductive decline reflects a gradual reproductive change. These approaches can therefore create different experimental contexts, which matters when interpreting hormonal, physiological, and treatment-related findings.
Reduced estrogen changes feedback within the hypothalamic-pituitary-ovarian axis, the signaling network linking the brain, pituitary gland, and ovaries. A menopause model can consequently examine endocrine disruption alongside downstream physiological effects. Focusing on this axis helps investigators connect ovarian hormone loss with broader changes rather than treating each symptom as an isolated outcome.
Depending on the model and study goal, investigators can examine vasomotor symptoms, bone loss, cardiovascular effects, cognitive changes, and genitourinary health. These outcomes represent different consequences of altered ovarian hormone status. Studying several endpoints within an experimental system can help clarify how menopause-related hormonal changes affect multiple areas of physiology.
Model selection influences how closely experimental findings reflect human menopause. A system based on ovariectomy, follicle destruction, or age-related reproductive decline represents a different pattern of reproductive change. That distinction affects interpretation of physiological outcomes and the relevance of treatment results, so investigators must consider the model’s relationship to the clinical question.
A study typically begins by choosing an experimental approach that produces ovarian hormone depletion, such as ovariectomy, follicle destruction, or observation of age-related reproductive decline. Investigators then examine relevant hormonal or physiological outcomes and use the system to evaluate an intervention or preventive strategy. The selected approach should match the research question.
These models provide experimental settings for evaluating hormone therapies, nonhormonal treatments, and preventive strategies. Researchers can examine whether an intervention affects menopause-associated outcomes such as vasomotor symptoms, bone loss, cardiovascular effects, cognitive changes, or genitourinary health. Findings support comparison of approaches before considering their relevance to human medicine.
In medicine, menopause models help investigators connect ovarian hormone depletion with changes across several physiological systems. They can support research on symptom mechanisms, consequences for bone and cardiovascular health, cognitive effects, genitourinary changes, and potential prevention. Their value extends beyond one symptom because they allow menopause-related effects and interventions to be studied experimentally.