Parenchymal Splitting
Parenchymal Splitting - Related Videos
09:49
Isolation and Cannulation of Cerebral Parenchymal Arterioles
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Cited by 28 •
2016
This manuscript describes a simple and reproducible protocol for isolation of intracerebral arterioles (a group of blood vessels encompassing parenchymal arterioles, penetrating arterioles and pre-capillary arterioles) from mice, to be used in pressure myography, immunofluorescence, biochemistry, and molecular studies.
10:37
The Split Brain
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California The study of how damage to the brain affects cognitive functioning has historically been one of the most important tools for cognitive neuroscience. While the brain is one of the most well protected parts of the body, there are many events that can affect the functioning of the brain. Vascular issues, tumors, degenerative diseases, infections, blunt force traumas, and neurosurgery are just some of the...
03:41
Preparing Cerebral Endothelial Tubes from Mouse Parenchymal Arterioles
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2025
This video demonstrates a method for isolating the endothelial tubes from mouse cerebral parenchyma. Through a combination of enzymatic digestion and mechanical dissociation, the process yields an intact tube with endothelial cells.
01:23
Stock Split
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2025
A stock split is a corporate action aimed at increasing the number of a company's shares by dividing its existing shares into multiple new ones. This adjustment reduces the per-share price without altering the company's overall market capitalization, thereby making shares more affordable to investors and enhancing trading flexibility. Stock splits are often employed by companies whose stock prices have risen significantly, making their shares less accessible to retail investors. Lowering the...
06:40
From MEFs to Matrigel 2: Splitting hESCs from MEFs onto Matrigel
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Cited by 4 •
2008
This video demonstrates how to maintain the growth of human embryonic stem cells (hESCs) in feeder cell-free conditions and how to continuously passage hESCs in feeder cell-free conditions. Confirmation of hESC pluripotency grown in feeder cell-free conditions by immunofluorescence microscopy is also demonstrated. Part 2 of 3.
FAQs
The technique separates the intended remnant from the diseased liver portion along a planned anatomical plane. When combined with portal vein ligation or occlusion, this arrangement redirects portal blood flow toward the remnant. The altered circulation stimulates rapid hypertrophy, increasing the volume of functioning liver available before the diseased portion is removed in a later stage.
Splitting alone divides the liver tissue, whereas portal vein ligation or occlusion changes the distribution of portal blood flow. Using both measures supports hypertrophy of the future liver remnant during staged treatment. This combination is central to approaches such as associating liver partition and portal vein ligation for staged hepatectomy, particularly when tumor burden initially limits resection.
The plane separates tissue that will remain functional from the diseased portion targeted for later removal. Precise planning therefore supports both preservation of the intended remnant and removal of the tumor-bearing tissue. Because the technique is performed during complex liver surgery, anatomical accuracy contributes to operative planning and helps determine whether adequate liver function can be maintained.
The process begins with operative planning that identifies the future liver remnant and the diseased portion. Surgeons then divide the parenchyma along the selected plane, often while performing portal vein ligation or occlusion. During the staged interval, portal flow supports remnant hypertrophy, after which the diseased portion can be addressed in the subsequent stage of hepatectomy.
This approach may be considered when a tumor is otherwise regarded as unresectable because the remaining functional liver would be inadequate after conventional tumor removal. By stimulating hypertrophy of the future remnant before completing resection, staged surgery can convert some previously unresectable tumors into operable cases. Its use still depends on careful patient selection and operative planning.
Appropriateness depends on whether the planned operation can preserve an adequate future liver remnant and whether the anatomy permits precise surgical planning. The disease distribution, the portion intended for removal, and the expected remnant must be assessed together. Because the procedure carries substantial surgical risk, selection requires careful consideration rather than relying on tumor resectability alone.