Preclinical Transplant Model
Preclinical Transplant Model - Related Videos
05:36
Kidney Procurement in a Preclinical Large Animal Model
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2025
Here, we present a protocol that details a surgical model for kidney procurement in a preclinical swine model for subsequent machine perfusion or transplantation.
07:45
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Cited by 15 •
2020
Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug response.
06:51
A Preclinical Murine Model of Hepatic Metastases
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Cited by 119 •
2014
A preclinical, murine model of hepatic metastases performed via a hemispleen injection technique.
06:55
A Preclinical Model of Orthotopic Heart Transplantation in Bama Miniature Pigs Using Biatrial Technique
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2025
This study proposes a preclinical orthotopic heart transplantation model in Bama miniature pigs, utilizing the biatrial technique. The model is applicable for transplant immunology, drug evaluation, and surgical technique optimization, providing support for clinical heart transplantation applications.
09:46
Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
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Cited by 5 •
2009
This video demonstrates how to use a preclinical inexpensive and reliable model to study pathobiological and pathophysiological processes of in-stent restenosis development. Longitudinal in vivo monitoring using OCT (Optical Coherence Tomography) and analysis of OCT images are also demonstrated.
FAQs
These processes jointly influence whether a graft remains viable and functional. Immune recognition can trigger inflammation, while vascular integration determines how effectively the transplanted material connects with the recipient’s circulation. Monitoring all three provides a more complete view than measuring graft survival alone, helping researchers identify biological barriers that may require surgical or therapeutic intervention.
Rejection mechanisms and treatment effects must be evaluated together because immunosuppressive therapy can alter immune recognition, inflammation, graft survival, and function. A preclinical transplant model allows investigators to examine these relationships under controlled conditions before clinical testing. The resulting evidence can support refinement of treatment strategies while also revealing whether a graft performs safely under the proposed regimen.
They provide a controlled setting for testing whether an emerging strategy can reduce harmful immune responses to transplanted cells, tissues, or organs. Researchers can compare graft performance and survival while monitoring immune recognition and inflammation. This makes the model useful for determining whether tolerance induction could reduce dependence on conventional immunosuppressive treatment before a strategy advances toward clinical evaluation.
A typical study places donor cells, tissue, or an organ into a recipient organism, applies the planned surgical or therapeutic conditions, and monitors the graft over time. Investigators assess survival, function, immune recognition, inflammation, and vascular integration. These observations help determine how the intervention performs and which protocol elements require optimization before clinical testing.
Researchers use the model when a surgical protocol, therapeutic approach, or graft strategy requires evaluation before human studies. Controlled testing can reveal how procedural choices affect graft performance and safety, while comparisons of outcomes help identify a more effective approach. This evidence supports systematic refinement rather than relying solely on results from laboratory development or clinical experimentation.
In addition to survival, they can show how a graft functions, integrates with the recipient’s vasculature, responds to immune recognition, and is affected by inflammation or immunosuppressive treatment. They also help connect laboratory findings with expected clinical outcomes. This broader information supports assessment of safety and guides development of tissue-engineering and immune-modifying transplantation strategies.