Rotor Test
Rotor Test - Related Videos
09:45
Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
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Cited by 17 •
2012
Fluorescence Lifetime Imaging (FLIM) has emerged as a key technique to image the environment and interaction of specific proteins and dyes in living cells. FLIM of fluorescent molecular rotors allows mapping of viscosity in living cells.
09:26
How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges
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Cited by 1 •
2016
Here we describe how to build a robust spring-transport mechanism for a spinning rotor gauge. This device securely immobilizes the rotor and keeps it under vacuum during transportation. We also describe packaging that minimizes the risk of damage during transport. Tests show our design works for typical shocks during transport.
06:23
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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Cited by 8 •
2020
Presented here is a protocol for chronic sleep fragmentation (CSF) model achieved by an electrically controlled orbital rotor, which could induce confirmed cognitive deficit and anxiety-like behavior in young wild-type mice. This model can be applied to explore the pathogenesis of chronic sleep disturbance and related disorders.
07:58
Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools
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Cited by 10 •
2020
Here, we present a protocol to use a curvelet transform-based, open-source MATLAB software tool for quantifying fibrillar collagen organization in the extracellular matrix of both normal and diseased tissues. This tool can be applied to images with collagen fibers or other types of line-like structures.
09:30
Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
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Cited by 2 •
2023
The protocol summarizes the best practices to minimize microbial bioburden in a cleanroom environment and includes strategies such as environmental monitoring, process monitoring, and product sterility testing. It is relevant for manufacturing and testing facilities that are required to meet current good tissue practice standards and current good manufacturing practice standards.
FAQs
Coproporphyrin measurement provides an indirect window into hepatic handling of bilirubin. In Rotor syndrome, impaired hepatic storage and reuptake of conjugated bilirubin changes how related pigment material is eliminated through urine. Evaluating both the quantity and excretion pattern therefore supports recognition of altered transport rather than relying on bilirubin concentration alone.
Rotor test findings are interpreted as part of a broader comparison rather than as a standalone label. Urinary coproporphyrin amount and pattern, together with serum bilirubin, liver enzymes, and other investigations, can help clinicians separate Rotor syndrome from Dubin-Johnson syndrome. The test therefore contributes to differential diagnosis without replacing full clinical assessment.
These accompanying results place urinary coproporphyrin findings in the context of the patient's overall liver profile. Serum bilirubin concentrations indicate the degree and type of bilirubin abnormality, while liver enzyme results help assess whether hepatobiliary disease should be considered. Reviewing them together reduces the risk of interpreting an isolated urinary result incorrectly.
At its core, the assessment requires evaluating urinary coproporphyrin excretion, including its amount and pattern. The result is not interpreted as an isolated yes-or-no finding; clinicians compare it with serum bilirubin concentrations, liver enzyme results, and other investigations. This combined approach helps place pigment findings within the broader evaluation of jaundice.
It is most relevant when jaundice remains unexplained and a benign inherited disorder of conjugated bilirubin handling is being considered. The test can contribute evidence for Rotor syndrome while clinicians assess competing explanations, including Dubin-Johnson syndrome and hepatobiliary disease. Its value lies in narrowing the differential diagnosis rather than independently establishing every cause of jaundice.
Genetic testing and modern biochemical analyses may provide additional confirmation, whereas urinary coproporphyrin evaluation supplies a biochemical perspective on pigment handling. These approaches can complement the clinical laboratory picture, especially when bilirubin, enzyme results, and urinary findings need clarification. Interpretation remains comparative and context dependent rather than based on one measurement alone.