Cortical Structures
Cortical Structures - Related Videos
10:36
Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons
0 Views •
Cited by 22 •
2014
To understand the structure of neuronal networks, functional and morphological characterization of individual neurons is a necessity. Here, we demonstrate juxtasomal biocytin labeling, which allows electrophysiological recordings in the extracellular configuration, yet maintaining the ability to intracellularly label the neuron for post hoc reconstruction of dendritic and axonal architecture.
09:00
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
0 Views •
Cited by 3 •
2015
Stereotactic Electroencephalography (SEEG) is an operative technique used in epilepsy surgery to help localize seizure foci. It also affords a unique opportunity to investigate brain function. Here we describe how SEEG can be used to investigate cognitive processes in human subjects.
09:09
Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data
0 Views •
Cited by 17 •
2015
To investigate flow velocities and directionality of filamentous-actin at the T cell immunological synapse, live-cell super-resolution imaging is combined with total internal reflection fluorescence and quantified with spatio-temporal image correlation spectroscopy.
09:45
In vivo Imaging of Deep Cortical Layers using a Microprism
0 Views •
Cited by 11 •
2009
Right-angle microprisms inserted into the mouse neocortex allows for deep imaging of multiple cortical layers with a viewpoint typically found in slice. One-millimeter microprisms offer a wide field-of-view (~900 μm) and spatial resolutions sufficient to resolve dendritic spines. We demonstrate layer V neuronal imaging and neocortical vascular imaging using microprisms.
02:04
Detection of Neuronal Aging in a Cortical Organoid Section
0 Views •
2025
This video demonstrates the method of detecting aging neurons in cortical organoid sections by staining for beta-galactosidase activity, which is elevated in senescent cells. The enzyme cleaves a substrate to produce a blue product, followed by microscopic observation of the stained neurons.
FAQs
Layered organization places specialized neurons into circuits that can process and relay information within the cortex. These layers do not act as isolated units: local pathways connect nearby neuronal populations, while long-range fiber tracts link distant regions. Together, this architecture supports integration across sensory, motor, and association areas.
Local pathways support interactions among nearby cortical neurons, whereas long-range fiber tracts connect separated regions. This distinction helps explain how processing can remain specialized within a region while still contributing to broader functions. In neuroscience, examining both connection scales is therefore important for understanding how sensory, motor, and association areas work together.
The frontal, parietal, temporal, and occipital cortices provide an anatomical framework for relating regions to different functions. Their study does not imply that perception, movement, memory, language, or decision-making belongs to one isolated location. Because cortical areas are connected, researchers can examine how specialized regions contribute to integrated behavior and cognition.
Mapping begins by relating anatomical regions to observed function, using neuroimaging and electrophysiological methods to investigate cortical activity and functional change. Researchers can compare signals across cortical areas and connect those patterns with behavior or cognition. This approach complements anatomical examination by showing how organized regions participate during normal function or after change.
Cortical mapping can link anatomical organization with perception, movement, memory, language, and decision-making, while also revealing how activity or function changes over time or after disruption. By comparing regions and their connections, researchers gain a framework for interpreting behavioral and cognitive effects rather than treating each observed function as independent.
Mapping cortical structures supports research on brain development, neurological disorders, and brain injury, while also helping identify functional changes measured with neuroimaging and electrophysiological methods. This application connects anatomy with changes in behavior and cognition. It gives neuroscience a common framework for studying organized cortical regions and altered function.