Mature Animals
Mature Animals - Related Videos
01:28
Maturation of Endosomes
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2023
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB). Changes in location The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
26:43
Computer-Generated Animal Model Stimuli
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Cited by 8 •
2007
Computer-generated stimuli using the Jacky dragon as a model.
07:52
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
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Cited by 1 •
2012
We describe a strategy to monitor maturation and migration of pulmonary dendritic cells in response to ovalbumin in the setting of ovalbumin induced allergic airway inflammation. This strategy can be modified to assess migration of pulmonary dendritic cells in settings of infection.
08:12
In Vitro Differentiation of Mature Myofibers for Live Imaging
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Cited by 38 •
2017
Muscle cells are among the most complex eukaryotic cells. We present a protocol for the in vitro differentiation of highly mature myofibers that allows for genetic manipulation and clear imaging during all developmental stages.
07:03
Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
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Cited by 75 •
2011
Oocytes are prone to aneuploidy due to errors in chromosome segregation during meiotic maturation. Aneuploid eggs can cause infertility, miscarriages or developmental disorders like Down syndrome. Here, we describe methods to introduce materials of choice into oocytes and methods to study meiotic maturation and assess ploidy.
FAQs
Their established organs, behaviors, and physiological systems provide a reference point for studying neural function after development has largely stabilized. Researchers can compare this adult baseline with developmental processes, injury responses, or age-associated alterations. This comparison helps identify whether a change reflects normal adult operation or a distinct transition caused by maturation, damage, or aging.
They combine behavioral testing with measurements of brain structure or activity under controlled conditions. Observations from intact animals show what the organism does, while electrophysiology, imaging, or molecular analysis provides complementary information about neural function. Together, these approaches help relate circuit activity to sensation, movement, learning, memory, and disease-related changes.
Established circuits allow researchers to examine how ongoing neural organization supports specific behaviors without focusing primarily on circuit formation. This stability helps investigations link brain structure and activity with sensory responses, movement, learning, and memory. It also creates a comparison framework for identifying alterations associated with injury, disease-related changes, or age-associated changes.
A study may integrate observations of intact animals and behavioral testing with electrophysiology, imaging, or molecular analysis. Behavioral assays characterize what the animal does, electrophysiology and imaging examine neural activity or related changes, and molecular analysis adds information about biological processes. Using complementary methods can connect behavioral outcomes with circuit-level and molecular findings.
Researchers first observe the intact animal or apply a defined behavioral test under controlled conditions. They then collect complementary evidence through electrophysiology, imaging, or molecular analysis, depending on the question. Finally, the measurements are interpreted alongside the behavior to determine how neural structure or activity relates to the tested function or change.
These models support studies of sensation, movement, learning, memory, and disease-related neural changes. They are especially useful when the goal is to understand how established neural systems operate in an adult organism rather than how those systems develop. Findings can also establish normal adult function against which injury responses or age-associated alterations are evaluated.