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JoVE Journal
Biology

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Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
 

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment

Article DOI: 10.3791/2851
July 23rd, 2011

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Summary July 23rd, 2011

Oocytes are prone to aneuploidy due to errors in chromosome segregation during meiotic maturation. Aneuploid eggs can cause infertility, miscarriages or developmental disorders like Down syndrome. Here, we describe methods to introduce materials of choice into oocytes and methods to study meiotic maturation and assess ploidy.

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